SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo

Abstract

Changing with the times Pandemic spread of a virus in naïe populations can select for mutations that alter pathogenesis, virulence, and/or transmissibility. The ancestral form of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that emerged from China has now been largely replaced by strains containing the mutation D614G (Asp 614 -to-Gly) in the viral spike protein. Hou et al. compared the characteristics of the new variant against the ancestral form in a series of experiments in human cells and animal models. The variant is better at infecting upper-airway epithelial cells and replicates in greater numbers than the ancestral virus. Evidence indicates modest, if any, significant changes to virulence in animal models. Therefore, the virus appears to have evolved for greater transmissibility in humans rather than for greater pathogenicity. The mutation renders the new virus variant more susceptible to neutralizing antisera without altering the efficacy of vaccine candidates currently under development. Science , this issue p. 1464

Cited by papers we hold 32

• Characterization of Two Heterogeneous Lethal Mouse-Adapted SARS-CoV-2 Variants Recapitulating Representative Aspects of Human COVID-19 · 2022
  Not checked
• Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms · 2022
  No notice
• The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in nonhuman primates and has an extended half-life in humans · 2022
  No notice
• SARS-CoV-2 Vaccines Based on the Spike Glycoprotein and Implications of New Viral Variants · 2021
  No notice
• SARS-CoV-2 disease severity and transmission efficiency is increased for airborne compared to fomite exposure in Syrian hamsters · 2021
  No notice
• SARS CoV-2 Delta variant exhibits enhanced infectivity and a minor decrease in neutralization sensitivity to convalescent or post-vaccination sera · 2021
  Not checked
• Detailed phylogenetic analysis tracks transmission of distinct SARS-COV-2 variants from China and Europe to West Africa · 2021
  Not checked
• Emergence of novel SARS-CoV-2 variants in the Netherlands · 2021
  Not checked
• Modeling the onset of symptoms of COVID-19: Effects of SARS-CoV-2 variant. · 2021
  Not checked
• Animal Models for COVID-19: Hamsters, Mouse, Ferret, Mink, Tree Shrew, and Non-human Primates · 2021
  Not checked
• Landscape of epitopes targeted by T cells in 852 individuals recovered from COVID-19: Meta-analysis, immunoprevalence, and web platform · 2021
  Not checked
• CVnCoV and CV2CoV protect human ACE2 transgenic mice from ancestral B BavPat1 and emerging B.1.351 SARS-CoV-2 · 2021
  Not checked
• Characterization of SARS-CoV-2 Variants N501Y.V1 and N501Y.V2 Spike on Viral Infectivity · 2021
  Not checked
• Experimental Evidence for Enhanced Receptor Binding by Rapidly Spreading SARS-CoV-2 Variants · 2021
  No notice
• SARS-CoV-2 neutralizing antibodies: Longevity, breadth, and evasion by emerging viral variants · 2021
  No notice
• Emerging SARS-CoV-2 variants of concern and potential intervention approaches · 2021
  No notice
• Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants · 2021
  No notice
• In vitro selection of Remdesivir resistance suggests evolutionary predictability of SARS-CoV-2 · 2021
  No notice
• Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation · 2021
  No notice
• SARS-CoV-2 within-host diversity and transmission · 2021
  No notice

and 12 more

Reads

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.