No retraction, correction or concern found when last checked on Oct 22, 2026.
High-resolution structures of the SARS-CoV-2 2′- O -methyltransferase reveal strategies for structure-based inhibitor design
Monica Rosas-Lemus, George Minasov, Ludmilla Shuvalova and 4 more
Science Signaling · 2020 · CC BY
Abstract
Crystal structures of an mRNA-capping enzyme from SARS-CoV-2 in complex with its substrates suggest targets for drug design.
References 62
- 1.
- 2.
Dong E, Du H, Gardner L, An interactive web-based dashboard to track COVID-19 in real time. Lancet Infect Dis, (2020 ).
Not in our library10.1016/s1473-3099(20)30120-1
- 3.
- 4.
- 5.
Petersen E, Koopmans M, Go U, Hamer DH, Petrosillo N, Castelli F, Storgaard M, Al Khalili S, Simonsen L, Comparing SARS-CoV-2 with SARS-CoV and influenza pandemics. Lancet Infect Dis, (2020 ).
Not in our library10.1016/s1473-3099(20)30484-9
- 6.
Kim D, Lee JY, Yang JS, Kim JW, Kim VN, Chang H, The Architecture of SARS-CoV-2 Transcriptome. Cell 181, 914–921 e910 (2020 ).
Not in our library10.1016/j.cell.2020.04.011
- 7.
Sedova M, Jaroszewski L, Alisoltani A, Godzik A, Coronavirus3D: 3D structural visualization of COVID-19 genomic divergence. Bioinformatics, (2020 ).
Not in our library10.1093/bioinformatics/btaa550
- 8.
Sola I, Almazan F, Zuniga S, Enjuanes L, Continuous and Discontinuous RNA Synthesis in Coronaviruses. Annu Rev Virol 2, 265–288 (2015 ).
Not in our library10.1146/annurev-virology-100114-055218
- 9.
Masters PS, The molecular biology of coronaviruses. Adv Virus Res 66, 193–292 (2006 ).
Not in our library10.1016/s0065-3527(06)66005-3
- 10.
Ramanathan A, Robb GB, Chan SH, mRNA capping: biological functions and applications. Nucleic Acids Res 44, 7511–7526 (2016 ).
Not in our library10.1093/nar/gkw551
- 11.
Furuichi Y, Shatkin AJ, Viral and cellular mRNA capping: past and prospects. Adv Virus Res 55, 135–184 (2000 ).
Not in our library10.1016/s0065-3527(00)55003-9
- 12.
Hussain S, Pan J, Chen Y, Yang Y, Xu J, Peng Y, Wu Y, Li Z, Zhu Y, Tien P, Guo D, Identification of novel subgenomic RNAs and noncanonical transcription initiation signals of severe acute respiratory syndrome coronavirus. J Virol 79, 5288–5295 (2005 ).
Not in our library10.1128/jvi.79.9.5288-5295.2005
- 13.
Ivanov KA, Thiel V, Dobbe JC, van der Meer Y, Snijder EJ, Ziebuhr J, Multiple enzymatic activities associated with severe acute respiratory syndrome coronavirus helicase. J Virol 78, 5619–5632 (2004 ).
Not in our library10.1128/jvi.78.11.5619-5632.2004
- 14.
Chen Y, Cai H, Pan J. a., Xiang N, Tien P, Ahola T, Guo D, Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase. Proceedings of the National Academy of Sciences 106, 3484–3489 (2009 ).
Not in our library10.1073/pnas.0808790106
- 15.
Minskaia E, Hertzig T, Gorbalenya AE, Campanacci V, Cambillau C, Canard B, Ziebuhr J, Discovery of an RNA virus 3’->5’ exoribonuclease that is critically involved in coronavirus RNA synthesis. Proc Natl Acad Sci U S A 103, 5108–5113 (2006 ).
Not in our library10.1073/pnas.0508200103
- 16.
- 17.
von Grotthuss M, Wyrwicz LS, Rychlewski L, mRNA cap-1 methyltransferase in the SARS genome. Cell 113, 701–702 (2003 ).
Not in our library10.1016/s0092-8674(03)00424-0
- 18.
- 19.
Chen Y, Guo D, Molecular mechanisms of coronavirus RNA capping and methylation. Virol Sin 31, 3–11 (2016 ).
Not in our library10.1007/s12250-016-3726-4
- 20.
Joseph JS, Saikatendu KS, Subramanian V, Neuman BW, Brooun A, Griffith M, Moy K, Yadav MK, Velasquez J, Buchmeier MJ, Stevens RC, Kuhn P, Crystal structure of nonstructural protein 10 from the severe acute respiratory syndrome coronavirus reveals a novel fold with two zinc-binding motifs. J Virol 80, 7894–7901 (2006 ).
Not in our library10.1128/jvi.00467-06
- 21.
Su D, Lou Z, Sun F, Zhai Y, Yang H, Zhang R, Joachimiak A, Zhang XC, Bartlam M, Rao Z, Dodecamer structure of severe acute respiratory syndrome coronavirus nonstructural protein nsp10. J Virol 80, 7902–7908 (2006 ).
Not in our library10.1128/jvi.00483-06
- 22.
- 23.
- 24.
Matthes N, Mesters JR, Coutard B, Canard B, Snijder EJ, Moll R, Hilgenfeld R, The non-structural protein Nsp10 of mouse hepatitis virus binds zinc ions and nucleic acids. FEBS Lett 580, 4143–4149 (2006 ).
Not in our library10.1016/j.febslet.2006.06.061
- 25.
Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O’Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Huettenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O’Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d’Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, Garcia-Sastre A, Shokat KM, Shoichet BK, Krogan NJ, A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature, (2020 ).
Not in our library10.1038/s41586-020-2286-9
- 26.
Debarnot C, Imbert I, Ferron F, Gluais L, Varlet I, Papageorgiou N, Bouvet M, Lescar J, Decroly E, Canard B, Crystallization and diffraction analysis of the SARS coronavirus nsp10-nsp16 complex. Acta Crystallogr Sect F Struct Biol Cryst Commun 67, 404–408 (2011 ).
Not in our library10.1107/s1744309111002867
- 27.
Wei SM, Yang L, Ke ZH, Liu QY, Che Y, Yang ZZ, Guo DY, Fan CP, Crystal structure of MERS-CoV nsp10/nsp16 complex bound to SAMor bound to SAM and m7GpppA. RCSB Protein Data Bank. DOI: 10.2210/pdb5YNM/pdb; DOI: 10.2210/pdb5YNM/pdb10.2210/pdb5YN6/pdb; DOI: 10.2210/pdb5YN6/pdb. Release date 12/05/2018.
Not in our library
- 28.
Wu A, Peng Y, Huang B, Ding X, Wang X, Niu P, Meng J, Zhu Z, Zhang Z, Wang J, Sheng J, Quan L, Xia Z, Tan W, Cheng G, Jiang T, Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China. Cell Host Microbe 27, 325–328 (2020 ).
Not in our library10.1016/j.chom.2020.02.001
- 29.
Ye Y, Godzik A, FATCAT: a web server for flexible structure comparison and structure similarity searching. Nucleic Acids Res 1, 582–585 (2004 ).
Not in our library10.1093/nar/gkh430
- 30.
Lugari A, Betzi S, Decroly E, Bonnaud E, Hermant A, Guillemot JC, Debarnot C, Borg JP, Bouvet M, Canard B, Morelli X, Lecine P, Molecular mapping of the RNA Cap 2’-O-methyltransferase activation interface between severe acute respiratory syndrome coronavirus nsp10 and nsp16. J Biol Chem 285, 33230–33241 (2010 ).
Not in our library10.1074/jbc.m110.120014
- 31.
Bollati M, Milani M, Mastrangelo E, Ricagno S, Tedeschi G, Nonnis S, Decroly E, Selisko B, de Lamballerie X, Coutard B, Canard B, Bolognesi M, Recognition of RNA cap in the Wesselsbron virus NS5 methyltransferase domain: implications for RNA-capping mechanisms in Flavivirus. J Mol Biol 385, 140–152 (2009 ).
Not in our library10.1016/j.jmb.2008.10.028
- 32.
Aouadi W, Blanjoie A, Vasseur JJ, Debart F, Canard B, Decroly E, Binding of the Methyl Donor S-Adenosyl-l-Methionine to Middle East Respiratory Syndrome Coronavirus 2’-O-Methyltransferase nsp16 Promotes Recruitment of the Allosteric Activator nsp10. J Virol 91, (2017 ).
Not in our library10.1128/jvi.02217-16
- 33.
Zhao Y, Soh TS, Lim SP, Chung KY, Swaminathan K, Vasudevan SG, Shi PY, Lescar J, Luo D, Molecular basis for specific viral RNA recognition and 2’-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5). Proc Natl Acad Sci U S A 112, 14834–14839 (2015 ).
Not in our library10.1073/pnas.1514978112
- 34.
- 35.
- 36.
Martinez MA, Compounds with Therapeutic Potential against Novel Respiratory 2019 Coronavirus. Antimicrob Agents Chemother 64, (2020 ).
Not in our library10.1128/aac.00399-20
- 37.
Kim Y, Jedrzejczak R, Maltseva N, Endres M, Godzik A, Joachimiak A, Center for Structural Genomics of Infectious Diseases (CSGID), Crystal Structure of the methyltransferase-stimulatory factor complex of NSP16 and NSP10 from SARS CoV-2. RCSB Protein Data Bank. DOI:. Release date 3/25/2020.
Not in our library10.2210/pdb6w61/pdb
- 38.
Yan LM, Huang YC, Lou ZY, Rao ZH, Crystal structure of 2019-nCoV nsp16-nsp10 complex. RCSB Protein Data Bank. DOI:. Release date 3/24/2020.,
Not in our library10.2210/pdb7bq7/pdb
- 39.
Lin S, Chen H, Ye F, Chen Z, Yang F, Zheng Y, Cao Y, Qiao J, Yang S, Lu G, Crystal structure of SARS-CoV-2 nsp10/nsp16 2’-O-methylase and its implication on antiviral drug design. Signal Transduct Target Ther 5, 131 (2020 ).
Not in our library10.1038/s41392-020-00241-4
- 40.
Schubert HL, Blumenthal RM, Cheng X, Many paths to methyltransfer: a chronicle of convergence. Trends Biochem Sci 28, 329–335 (2003 ).
Not in our library10.1016/s0968-0004(03)00090-2
Cited by papers we hold 3
- In silico analysis of SARS-CoV-2 proteins as targets for clinically available drugs · 2022Not checked
- Structural biology of SARS-CoV-2: open the door for novel therapies · 2022No notice
- Current status of structure-based drug repurposing against COVID-19 by targeting SARS-CoV-2 proteins · 2021Not checked
Reads
Read by people on this page
None yet.
Checked or read by AI through naulon
None yet.
A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.
Are you an author?
Is this your paper?
Claim it to add your note and be paid when agents cite it. Free.