A molecular pore spans the double membrane of the coronavirus replication organelle

Abstract

Viral RNA exported from the coronavirus replication organelle is likely to be mediated by a crown-shaped molecular pore.

References 50

1. 1.

   Ksiazek T. G., Erdman D., Goldsmith C. S., Zaki S. R., Peret T., Emery S., Tong S., Urbani C., Comer J. A., Lim W., Rollin P. E., Dowell S. F., Ling A. E., Humphrey C. D., Shieh W. J., Guarner J., Paddock C. D., Rota P., Fields B., DeRisi J., Yang J. Y., Cox N., Hughes J. M., LeDuc J. W., Bellini W. J., Anderson L. J., Group S. W.; SARS Working Group, A novel coronavirus associated with severe acute respiratory syndrome. N. Engl. J. Med. 348, 1953–1966 (2003 ).

   Not in our library10.1056/nejmoa030781

2. 2.

   Zaki A. M., van Boheemen S., Bestebroer T. M., Osterhaus A. D., Fouchier R. A., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N. Engl. J. Med. 367, 1814–1820 (2012 ).

   Not in our library10.1056/nejmoa1211721

3. 3.

   Zhu N., Zhang D., Wang W., Li X., Yang B., Song J., Zhao X., Huang B., Shi W., Lu R., Niu P., Zhan F., Ma X., Wang D., Xu W., Wu G., Gao G. F., Tan W., China Novel Coronavirus Investigating and Research Team, A novel coronavirus from patients with pneumonia in China, 2019. N. Engl. J. Med. 382, 727–733 (2020 ).

   Not in our library10.1056/nejmoa2001017

4. 4.
   SARS-Coronavirus Replication Is Supported by a Reticulovesicular Network of Modified Endoplasmic Reticulum · 2008

   No notice
5. 5.
   A unifying structural and functional model of the coronavirus replication organelle: Tracking down RNA synthesis · 2020

   No notice
6. 6.
   Infectious Bronchitis Virus Generates Spherules from Zippered Endoplasmic Reticulum Membranes · 2013

   No notice
7. 7.

   Ulasli M., Verheije M. H., de Haan C. A., Reggiori F., Qualitative and quantitative ultrastructural analysis of the membrane rearrangements induced by coronavirus. Cell. Microbiol. 12, 844–861 (2010 ).

   Not in our library10.1111/j.1462-5822.2010.01437.x

8. 8.

   de Haan C. A., Rottier P. J., Molecular interactions in the assembly of coronaviruses. Adv. Virus Res. 64, 165–230 (2005 ).

   Not in our library10.1016/s0065-3527(05)64006-7

9. 9.

   Abels J. A., Moreno-Herrero F., van der Heijden T., Dekker C., Dekker N. H., Single-molecule measurements of the persistence length of double-stranded RNA. Biophys. J. 88, 2737–2744 (2005 ).

   Not in our library10.1529/biophysj.104.052811

10. 10.

    Ding K., Celma C. C., Zhang X., Chang T., Shen W., Atanasov I., Roy P., Zhou Z. H., In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release. Nat. Commun. 10, 2216 (2019 ).

    Not in our library10.1038/s41467-019-10236-7

11. 11.
    Cryo-electron tomography reveals novel features of a viral RNA replication compartment · 2017

    Not checked
12. 12.

    Snijder E. J., Decroly E., Ziebuhr J., The nonstructural proteins directing coronavirus RNA synthesis and processing. Adv. Virus Res. 96, 59–126 (2016 ).

    Not in our library10.1016/bs.aivir.2016.08.008

13. 13.

    Oostra M., Hagemeijer M. C., van Gent M., Bekker C. P., te Lintelo E. G., Rottier P. J., de Haan C. A., Topology and membrane anchoring of the coronavirus replication complex: Not all hydrophobic domains of nsp3 and nsp6 are membrane spanning. J. Virol. 82, 12392–12405 (2008 ).

    Not in our library10.1128/jvi.01219-08

14. 14.

    Oostra M., te Lintelo E. G., Deijs M., Verheije M. H., Rottier P. J., de Haan C. A., Localization and membrane topology of coronavirus nonstructural protein 4: Involvement of the early secretory pathway in replication. J. Virol. 81, 12323–12336 (2007 ).

    Not in our library10.1128/jvi.01506-07

15. 15.

    Kanjanahaluethai A., Chen Z., Jukneliene D., Baker S. C., Membrane topology of murine coronavirus replicase nonstructural protein 3. Virology 361, 391–401 (2007 ).

    Not in our library10.1016/j.virol.2006.12.009

16. 16.

    Neuman B. W., Bioinformatics and functional analyses of coronavirus nonstructural proteins involved in the formation of replicative organelles. Antiviral Res. 135, 97–107 (2016 ).

    Not in our library10.1016/j.antiviral.2016.10.005

17. 17.

    Angelini M. M., Akhlaghpour M., Neuman B. W., Buchmeier M. J., Severe acute respiratory syndrome coronavirus nonstructural proteins 3, 4, and 6 induce double-membrane vesicles. mBio 4, e00524–e13 (2013 ).

    Not in our library10.1128/mbio.00524-13

18. 18.
    Expression and Cleavage of Middle East Respiratory Syndrome Coronavirus nsp3-4 Polyprotein Induce the Formation of Double-Membrane Vesicles That Mimic Those Associated with Coronaviral RNA Replication · 2017

    No notice
19. 19.

    Hagemeijer M. C., Monastyrska I., Griffith J., van der Sluijs P., Voortman J., van Bergen P. M., Henegouwen A. M., Vonk, P. J. Rottier, F. Reggiori, C. A. de Haan, Membrane rearrangements mediated by coronavirus nonstructural proteins 3 and 4. Virology 458–459, 125–135 (2014 ).

    Not in our library10.1016/j.virol.2014.04.027

20. 20.

    Lei J., Kusov Y., Hilgenfeld R., Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein. Antiviral Res. 149, 58–74 (2018 ).

    Not in our library10.1016/j.antiviral.2017.11.001

21. 21.

    Serrano P., Johnson M. A., Almeida M. S., Horst R., Herrmann T., Joseph J. S., Neuman B. W., Subramanian V., Saikatendu K. S., Buchmeier M. J., Stevens R. C., Kuhn P., Wüthrich K., Nuclear magnetic resonance structure of the N-terminal domain of nonstructural protein 3 from the severe acute respiratory syndrome coronavirus. J. Virol. 81, 12049–12060 (2007 ).

    Not in our library10.1128/jvi.00969-07

22. 22.

    Hurst K. R., Koetzner C. A., Masters P. S., Characterization of a critical interaction between the coronavirus nucleocapsid protein and nonstructural protein 3 of the viral replicase-transcriptase complex. J. Virol. 87, 9159–9172 (2013 ).

    Not in our library10.1128/jvi.01275-13

23. 23.

    Cong Y., Ulasli M., Schepers H., Mauthe M., P. V’Kovski, F. Kriegenburg, V. Thiel, C. A. M. de Haan, F. Reggiori, Nucleocapsid protein recruitment to replication-transcription complexes plays a crucial role in coronaviral life cycle. J. Virol. 94, e01925–e19 (2020 ).

    Not in our library10.1128/jvi.01925-19

24. 24.

    Freeman M. C., Graham R. L., Lu X., Peek C. T., Denison M. R., Coronavirus replicase-reporter fusions provide quantitative analysis of replication and replication complex formation. J. Virol. 88, 5319–5327 (2014 ).

    Not in our library10.1128/jvi.00021-14

25. 25.

    Graham R. L., Sims A. C., Baric R. S., Denison M. R., The nsp2 proteins of mouse hepatitis virus and SARS coronavirus are dispensable for viral replication. Adv. Exp. Med. Biol. 581, 67–72 (2006 ).

    Not in our library10.1007/978-0-387-33012-9_10

26. 26.

    Gadlage M. J., Sparks J. S., Beachboard D. C., Cox R. G., Doyle J. D., Stobart C. C., Denison M. R., Murine hepatitis virus nonstructural protein 4 regulates virus-induced membrane modifications and replication complex function. J. Virol. 84, 280–290 (2010 ).

    Not in our library10.1128/jvi.01772-09

27. 27.
    Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors · 2019

    No notice
28. 28.

    Sevajol M., Subissi L., Decroly E., Canard B., Imbert I., Insights into RNA synthesis, capping, and proofreading mechanisms of SARS-coronavirus. Virus Res. 194, 90–99 (2014 ).

    Not in our library10.1016/j.virusres.2014.10.008

29. 29.

    Subissi L., Imbert I., Ferron F., Collet A., Coutard B., Decroly E., Canard B., SARS-CoV ORF1b-encoded nonstructural proteins 12-16: Replicative enzymes as antiviral targets. Antiviral Res. 101, 122–130 (2014 ).

    Not in our library10.1016/j.antiviral.2013.11.006

30. 30.

    Gui M., Liu X., Guo D., Zhang Z., Yin C. C., Chen Y., Xiang Y., Electron microscopy studies of the coronavirus ribonucleoprotein complex. Protein Cell 8, 219–224 (2017 ).

    Not in our library10.1007/s13238-016-0352-8

31. 31.
    SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology · 2020

    No notice
32. 32.

    Kuo L., Koetzner C. A., Masters P. S., A key role for the carboxy-terminal tail of the murine coronavirus nucleocapsid protein in coordination of genome packaging. Virology 494, 100–107 (2016 ).

    Not in our library10.1016/j.virol.2016.04.009

33. 33.

    Caly L., Druce J., Roberts J., Bond K., Tran T., Kostecki R., Yoga Y., Naughton W., Taiaroa G., Seemann T., Schultz M. B., Howden B. P., Korman T. M., Lewin S. R., Williamson D. A., Catton M. G., Isolation and rapid sharing of the 2019 novel coronavirus (SARS-CoV-2) from the first patient diagnosed with COVID-19 in Australia. Med. J. Aust. 212, 459–462 (2020 ).

    Not in our library10.5694/mja2.50569

34. 34.

    Wolff G., Limpens R. W. A. L., Zheng S., Snijder E. J., Agard D. A., Koster A. J., Bárcena M., Mind the gap: Micro-expansion joints drastically decrease the bending of FIB-milled cryo-lamellae. J. Struct. Biol. 208, 107389 (2019 ).

    Not in our library10.1016/j.jsb.2019.09.006

35. 35.
    Implementation of a cryo-electron tomography tilt-scheme optimized for high resolution subtomogram averaging · 2017

    No notice
36. 36.

    Zheng S. Q., Palovcak E., Armache J. P., Verba K. A., Cheng Y., Agard D. A., MotionCor2: Anisotropic correction of beam-induced motion for improved cryo-electron microscopy. Nat. Methods 14, 331–332 (2017 ).

    Not in our library10.1038/nmeth.4193

37. 37.

    Rohou A., Grigorieff N., CTFFIND4: Fast and accurate defocus estimation from electron micrographs. J. Struct. Biol. 192, 216–221 (2015 ).

    Not in our library10.1016/j.jsb.2015.08.008

38. 38.

    Xiong Q., Morphew M. K., Schwartz C. L., Hoenger A. H., Mastronarde D. N., CTF determination and correction for low dose tomographic tilt series. J. Struct. Biol. 168, 378–387 (2009 ).

    Not in our library10.1016/j.jsb.2009.08.016

39. 39.

    Frangakis A. S., Hegerl R., Noise reduction in electron tomographic reconstructions using nonlinear anisotropic diffusion. J. Struct. Biol. 135, 239–250 (2001 ).

    Not in our library10.1006/jsbi.2001.4406

40. 40.

    Kremer J. R., Mastronarde D. N., McIntosh J. R., Computer visualization of three-dimensional image data using IMOD. J. Struct. Biol. 116, 71–76 (1996 ).

    Not in our library10.1006/jsbi.1996.0013

Cited by papers we hold 14

• The role of autophagy in viral infections · 2023
  No notice
• Tunneling nanotubes provide a route for SARS-CoV-2 spreading · 2022
  No notice
• SARS-CoV-2 nucleocapsid protein adheres to replication organelles before viral assembly at the Golgi/ERGIC and lysosome-mediated egress · 2022
  No notice
• Molecular architecture of the Chikungunya virus replication complex · 2022
  No notice
• SARS-CoV-2 Causes Mitochondrial Dysfunction and Mitophagy Impairment · 2022
  No notice
• The SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomes · 2021
  No notice
• Computational epitope map of SARS-CoV-2 spike protein · 2021
  No notice
• Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 · 2021
  No notice
• Patterns of within-host genetic diversity in SARS-CoV-2 · 2021
  No notice
• Correlative multi-scale cryo-imaging unveils SARS-CoV-2 assembly and egress · 2021
  No notice
• SARS-CoV-2 genomic and subgenomic RNAs in diagnostic samples are not an indicator of active replication · 2020
  No notice
• SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography · 2020
  No notice
• The Enzymatic Activity of the nsp14 Exoribonuclease Is Critical for Replication of MERS-CoV and SARS-CoV-2 · 2020
  No notice
• The SARS-CoV-2 RNA–protein interactome in infected human cells · 2020
  No notice

Reads

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.