Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

Abstract

Immune profiling of COVID-19 patients Coronavirus disease 2019 (COVID-19) has affected millions of people globally, yet how the human immune system responds to and influences COVID-19 severity remains unclear. Mathew et al. present a comprehensive atlas of immune modulation associated with COVID-19. They performed high-dimensional flow cytometry of hospitalized COVID-19 patients and found three prominent and distinct immunotypes that are related to disease severity and clinical parameters. Arunachalam et al. report a systems biology approach to assess the immune system of COVID-19 patients with mild-to-severe disease. These studies provide a compendium of immune cell information and roadmaps for potential therapeutic interventions. Science , this issue p. eabc8511 , p. 1210

Full text

Its licence does not allow us to show the full text. Read it at PubMed Central:

References 57

1. 1.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library

2. 2.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library10.1126/science.abb8925

3. 3.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library10.1038/s41418-020-0530-3

4. 4.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library10.1016/j.immuni.2020.05.002

5. 5.
   Phenotype and kinetics of SARS-CoV-2–specific T cells in COVID-19 patients with acute respiratory distress syndrome · 2020

   No notice
6. 6.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library10.1016/j.cell.2020.05.015

7. 7.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library

8. 8.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library10.1093/cid/ciaa248

9. 9.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library10.1016/j.gendis.2020.03.008

10. 10.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1016/j.eclinm.2020.100331

11. 11.
    Functional exhaustion of antiviral lymphocytes in COVID-19 patients · 2020

    No notice
12. 12.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1038/s41423-020-0401-3

13. 13.
    Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19) · 2020

    No notice
14. 14.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1146/annurev-immunol-041015-055318

15. 15.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1038/s41591-020-0819-2

16. 16.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1172/jci137244

17. 17.
    Lymphopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A systemic review and meta-analysis · 2020

    Not checked
18. 18.
    Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study · 2020

    Corrected
19. 19.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1016/s0140-6736(20)30183-5

20. 20.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

21. 21.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1038/s41591-020-0901-9

22. 22.
    Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing · 2020

    Corrected
23. 23.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

24. 24.
    Serum IgA, IgM, and IgG responses in COVID-19 · 2020

    No notice
25. 25.
    Severe Acute Respiratory Syndrome Coronavirus 2−Specific Antibody Responses in Coronavirus Disease Patients · 2020

    No notice
26. 26.
    Neutralizing Antibodies against SARS-CoV-2 and Other Human Coronaviruses · 2020

    Corrected
27. 27.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1016/j.immuni.2020.04.023

28. 28.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1001/jama.2020.4783

29. 29.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1002/jmv.20499

30. 30.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1038/s41577020-0311-8

31. 31.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1002/jmv.25819

32. 32.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

33. 33.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1038/cddis.2016.55

34. 34.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1016/j.immuni.2015.08.012

35. 35.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1016/j.immuni.2019.04.011

36. 36.
    Vaccine-induced ICOS+CD38+ circulating Tfh are sensitive biosensors of age-related changes in inflammatory pathways · 2021

    Not checked
37. 37.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.4049/jimmunol.1302503

38. 38.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1016/j.chom.2020.04.009

39. 39.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1126/sciimmunol.aag2152

40. 40.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

Cited by papers we hold 41

• Distinguishing features of long COVID identified through immune profiling · 2023
  No notice
• T cells in health and disease · 2023
  No notice
• Chronic inflammation, neutrophil activity, and autoreactivity splits long COVID · 2023
  No notice
• Sotigalimab and/or nivolumab with chemotherapy in first-line metastatic pancreatic cancer: clinical and immunologic analyses from the randomized phase 2 PRINCE trial · 2022
  No notice
• Multi-Cellular Immunological Interactions Associated With COVID-19 Infections · 2022
  Not checked
• mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functions · 2022
  No notice
• COVID-19 therapeutics: Challenges and directions for the future · 2022
  No notice
• Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19 · 2022
  No notice
• SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself · 2021
  No notice
• HERV-W envelope expression in blood leukocytes as a marker of disease severity of COVID-19 · 2021
  Not checked
• Multiorgan impairment in low-risk individuals with post-COVID-19 syndrome: a prospective, community-based study · 2021
  No notice
• Essential Fatty Acids and Their Metabolites in the Pathobiology of Inflammation and Its Resolution · 2021
  No notice
• Can NLRP3 inhibitors improve on dexamethasone for the treatment of COVID-19? · 2021
  Not checked
• T Cells Targeting SARS-CoV-2: By Infection, Vaccination, and Against Future Variants · 2021
  Not checked
• Peripheral and lung resident memory T cell responses against SARS-CoV-2 · 2021
  No notice
• SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8 + T cell responses · 2021
  No notice
• Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19 · 2021
  No notice
• Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy · 2021
  No notice
• Severely ill patients with COVID-19 display impaired exhaustion features in SARS-CoV-2–reactive CD8 + T cells · 2021
  No notice
• Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals after mRNA vaccination · 2021
  No notice

and 21 more

Reads

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.