Admixture into and within sub-Saharan Africa

Abstract

Similarity between two individuals in the combination of genetic markers along their chromosomes indicates shared ancestry and can be used to identify historical connections between different population groups due to admixture. We use a genome-wide, haplotype-based, analysis to characterise the structure of genetic diversity and gene-flow in a collection of 48 sub-Saharan African groups. We show that coastal populations experienced an influx of Eurasian haplotypes over the last 7000 years, and that Eastern and Southern Niger-Congo speaking groups share ancestry with Central West Africans as a result of recent population expansions. In fact, most sub-Saharan populations share ancestry with groups from outside of their current geographic region as a result of gene-flow within the last 4000 years. Our in-depth analysis provides insight into haplotype sharing across different ethno-linguistic groups and the recent movement of alleles into new environments, both of which are relevant to studies of genetic epidemiology.

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Cited by papers we hold 7

• Population genomics of post-glacial western Eurasia · 2024
  Corrected
• Leveraging Mann–Whitney U test on large-scale genetic variation data for analysing malaria genetic markers · 2022
  Not checked
• Organized to learn: the influence of social structure on social learning opportunities in a group · 2021
  Not checked
• Evaluating the promise of inclusion of African ancestry populations in genomics · 2020
  No notice
• Insights into malaria susceptibility using genome-wide data on 17,000 individuals from Africa, Asia and Oceania · 2019
  No notice
• Deciphering pyritization-kerogenization gradient for fish soft-tissue preservation · 2017
  Not checked
• Cardiovascular Disease Epidemiology in Portuguese-Speaking Countries: data from the Global Burden of Disease, 1990 to 2016
  Not checked

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