Antibody structure and engineering considerations for the design and function of Antibody Drug Conjugates (ADCs)

Abstract

Antibody-drug conjugates (ADCs) are emerging as effective tools in cancer therapy, combining the antibody's exquisite specificity for the target antigen-expressing cancer cell together with the cytotoxic potency of the payload. Much success stems from the rational design of "toxic warheads", chemically linked to antibodies, and from fine-tuning the intricate properties of chemical linkers. Here, we focus on the antibody moiety of ADCs, dissecting the impact of Fab, linkers, isotype and Fc structure on the anti-tumoral and immune-activating functions of ADCs. Novel design approaches informed by antibody structural attributes present opportunities that may contribute to the success of next generation ADCs.

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• A comprehensive overview on antibody-drug conjugates: from the conceptualization to cancer therapy · 2023
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• Antibody drug conjugate: the “biological missile” for targeted cancer therapy · 2022
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• An Insight into FDA Approved Antibody-Drug Conjugates for Cancer Therapy · 2021
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• Antibody–Drug Conjugates—A Tutorial Review · 2021
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• Antibody-Drug Conjugates: The New Frontier of Chemotherapy · 2020
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• Antibody–Drug Conjugates for Cancer Therapy · 2020
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