Synthesis and cytotoxic activity of some novel benzocoumarin derivatives under solvent free conditions
Anhar Abdel-Aziem, Huda Refaat Mahmoud Rashdan, Entesar Mohamed Ahmed and 1 more
Green Chemistry Letters and Reviews · 2019
doi:10.1080/17518253.2018.1556743 (opens in a new tab)
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Abstract
In the present study, a rapid, less expensive, clean and environmental friendly route to synthesis new pyrazoles, pyrazolopyridazines and condensed pyrimidines was developed via grinding of 2-(3-(dimethylamino)acryloyl)-3H-benzo[f]chromen-3-one (1) with different reagents. All the new compounds were characterized and established using elemental analysis and spectral data. Eight compounds were selected for in vitro antiproliferative against different human cancer cell lines entitled melanoma, cancers of the lung, leukemia, breast, brain, colon, prostate, ovary and kidney by the USA NCI.
Abstract licence: CC BY-NC
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