Anti‐inflammatory cytokines in asthma and allergy: interleukin‐10, interleukin‐12, interferon‐γ

Abstract

Interleukin‐10 (IL‐10) is a cytokine derived from T‐helper type 2 (T H2 ) cells identified as a suppressor of cytokines from T‐helper type 1(T H1 ) cells. Interleukin‐12 (IL‐12) is produced by B cells, macrophages and dendritic cells, and primarily regulates T H1 cell differentiation, while suppressing the expansion of T H2 cell clones. Interferon‐γ (IFN‐γ) is a product of T H1 cells and exerts inhibitory effects on T H2 cell differentiation. These cytokines have been implicated in the pathogenesis of asthma and allergies. In this context, IL‐12 and IFN‐γ production in asthma have been found to be decreased, and this may reduce their capacity to inhibit IgE synthesis and allergic inflammation. IL‐10 is a potent inhibitor of monocyte/macrophage function, suppressing the production of many pro‐inflammatory cytokines. A relative underproduction of IL‐10 from alveolar macrophages of atopic asthmatics has been reported. Therapeutic modulation of T H1 /T H2 imbalance in asthma and allergy by mycobacterial vaccine, specific immunotherapy and cytoline‐guanosine dinucleotide motif may lead to increases in IL‐12 and IFN‐γ production. Stimulation of IL‐10 production by antigen‐specific T‐cells during immunotherapy may lead to anergy through inhibition of CD28‐costimulatory molecule signalling by IL‐10s anti‐inflammatory effect on basophils, mast cells and eosinophils.

Cited by papers we hold 1

• Role played by Th2 type cytokines in IgE mediated allergy and asthma · 2010
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