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Structure of SARS-CoV-2 ORF8, a rapidly evolving immune evasion protein

Thomas G. Flower, Cosmo Z. Buffalo, Richard M. Hooy and 3 more

Proceedings of the National Academy of Sciences · 2020 · CC BY

doi:10.1073/pnas.2021785118

Abstract

Significance The structure of the SARS-CoV-2 ORF8 protein reveals two novel intermolecular interfaces layered onto an ORF7 fold. One is mediated by a disulfide bond, the other is noncovalent, and both are novel with respect to SARS-CoV. The structural analysis here establishes a molecular framework for understanding the rapid evolution of ORF8, its contributions to COVID-19 pathogenesis, and the potential for its neutralization by antibodies.

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