Sibling risks in cancer: clues to recessive or X-linked genes?

Abstract

A systematic analysis of cancer risks to offspring and to siblings of cancer cases was carried out based on the nation-wide Swedish Family-Cancer Database. For all 13 cancer sites examined, risks to both offspring and siblings of cases of cancer at the same site were significantly elevated. The relative risk to siblings was approximately 2 fold more than the offspring risk for cancers of the prostate, testis, kidney and bladder, suggesting that recessive or X-linked susceptibility genes may be important for these cancers. Risks to siblings of cases where a parent was also affected were increased >20 fold over population rates for colorectal, ovarian, prostate and renal cancer, and for leukaemia, consistent with the effects of rare high-risk susceptibility alleles.

References 19

1. 1.

   Ahlbom A., Lichtenstein P., Malmström H., Feychting M., Hemminki K., Pedersen N. L. Cancer in twins: genetic and nongenetic familial risk factors. J Natl Cancer Inst. 1997;89(4):287-293.

   Not in our library10.1093/jnci/89.4.287

2. 2.

   Antoniou A. C., Gayther S. A., Stratton J. F., Ponder B. A., Easton D. F. Risk models for familial ovarian and breast cancer. Genet Epidemiol. 2000;18(2):173-190.

   Not in our library10.1002/(sici)1098-2272(200002)18:2<173::aid-gepi6>3.0.co;2-r

3. 3.

   Carstensen B., Soll-Johanning H., Villadsen E., Søndergaard J. O., Lynge E. Familial aggregation of colorectal cancer in the general population. Int J Cancer. 1996;68(4):428-435.

   Not in our library10.1002/(sici)1097-0215(19961115)68:4<428::aid-ijc5>3.0.co;2-2

4. 4.

   Claus E. B., Schildkraut J., Iversen E. S., Berry D., Parmigiani G. Effect of BRCA1 and BRCA2 on the association between breast cancer risk and family history. J Natl Cancer Inst. 1998;90(23):1824-1829.

   Not in our library10.1093/jnci/90.23.1824

5. 5.

   Easton D. F., Matthews F. E., Ford D., Swerdlow A. J., Peto J. Cancer mortality in relatives of women with ovarian cancer: the OPCS Study. Office of Population Censuses and Surveys. Int J Cancer. 1996;65(3):284-294.

   Not in our library10.1002/(sici)1097-0215(19960126)65:3<284::aid-ijc2>3.0.co;2-w

6. 6.

   Fearon E. R. Human cancer syndromes: clues to the origin and nature of cancer. Science. 1997;278(5340):1043-1050.

   Not in our library10.1126/science.278.5340.1043

7. 7.

   Goldgar D. E., Easton D. F., Cannon-Albright L. A., Skolnick M. H. Systematic population-based assessment of cancer risk in first-degree relatives of cancer probands. J Natl Cancer Inst. 1994;86(21):1600-1608.

   Not in our library10.1093/jnci/86.21.1600

8. 8.

   Grönberg H., Smith J., Emanuelsson M., Jonsson B. A., Bergh A., Carpten J., Isaacs W., Xu J., Meyers D., Trent J. In Swedish families with hereditary prostate cancer, linkage to the HPC1 locus on chromosome 1q24-25 is restricted to families with early-onset prostate cancer. Am J Hum Genet. 1999;65(1):134-140.

   Not in our library10.1086/302447

9. 9.

   Hemminki K., Dong C. Lifestyle and cancer: protection from a cancer-free spouse. Int J Cancer. 2000;87(2):308-309.

   Not in our library

10. 10.

    Hemminki K., Vaittinen P., Kyyrönen P. Age-specific familial risks in common cancers of the offspring. Int J Cancer. 1998;78(2):172-175.

    Not in our library10.1002/(sici)1097-0215(19981005)78:2<172::aid-ijc9>3.0.co;2-w

11. 11.

    Hemminki K., Vaittinen P. National database of familial cancer in Sweden. Genet Epidemiol. 1998;15(3):225-236.

    Not in our library10.1002/(sici)1098-2272(1998)15:3<225::aid-gepi2>3.0.co;2-3

12. 12.

    Monroe K. R., Yu M. C., Kolonel L. N., Coetzee G. A., Wilkens L. R., Ross R. K., Henderson B. E. Evidence of an X-linked or recessive genetic component to prostate cancer risk. Nat Med. 1995;1(8):827-829.

    Not in our library10.1038/nm0895-827

13. 13.

    Narod S. Genetic epidemiology of prostate cancer. Biochim Biophys Acta. 1999;1423(1):F1-13.

    Not in our library10.1016/s0304-419x(98)00030-4

14. 14.

    Peto J., Collins N., Barfoot R., Seal S., Warren W., Rahman N., Easton D. F., Evans C., Deacon J., Stratton M. R. Prevalence of BRCA1 and BRCA2 gene mutations in patients with early-onset breast cancer. J Natl Cancer Inst. 1999;91(11):943-949.

    Not in our library10.1093/jnci/91.11.943

15. 15.

    Peto J., Easton D. F., Matthews F. E., Ford D., Swerdlow A. J. Cancer mortality in relatives of women with breast cancer: the OPCS Study. Office of Population Censuses and Surveys. Int J Cancer. 1996;65(3):275-283.

    Not in our library10.1002/(sici)1097-0215(19960126)65:3<275::aid-ijc1>3.0.co;2-x

16. 16.

    Pharoah P. D., Day N. E., Duffy S., Easton D. F., Ponder B. A. Family history and the risk of breast cancer: a systematic review and meta-analysis. Int J Cancer. 1997;71(5):800-809.

    Not in our library10.1002/(sici)1097-0215(19970529)71:5<800::aid-ijc18>3.0.co;2-b

17. 17.

    Rapley E. A., Crockford G. P., Teare D., Biggs P., Seal S., Barfoot R., Edwards S., Hamoudi R., Heimdal K., Fossâ S. D. Localization to Xq27 of a susceptibility gene for testicular germ-cell tumours. Nat Genet. 2000;24(2):197-200.

    Not in our library10.1038/72877

18. 18.

    Stratton J. F., Pharoah P., Smith S. K., Easton D., Ponder B. A. A systematic review and meta-analysis of family history and risk of ovarian cancer. Br J Obstet Gynaecol. 1998;105(5):493-499.

    Not in our library10.1111/j.1471-0528.1998.tb10148.x

19. 19.

    Szabo C. I., King M. C. Population genetics of BRCA1 and BRCA2. Am J Hum Genet. 1997;60(5):1013-1020.

    Not in our library

Cited by papers we hold 1

• Familial risk in testicular cancer as a clue to a heritable and environmental aetiology · 2004
  No notice

Reads

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.