Selective cancer cell killing by α-tocopheryl succinate
J Neuzil, T Weber, N Gellert and 1 more
British Journal of Cancer · 2001
doi:10.1054/bjoc.2000.1559 (opens in a new tab)
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Abstract
We report that alpha-tocopheryl succinate, a vitamin E analogue with pro-apoptotic properties, selectively kills cells with a malignant or transformed phenotype, i.e. multiple haematopoietic and carcinoma cell lines, while being non-toxic to normal, i.e. primary and non-transformed cells. These findings strongly suggest a potential of this micronutrient in the therapy and/or prevention of cancer without significant side-effects.
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