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Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion

J H W de Wilt, T L M ten Hagen, G de Boeck and 3 more

British Journal of Cancer · 2000

doi:10.1054/bjoc.1999.1032

Abstract

Several possible mechanisms for the synergistic anti-tumour effects between tumour necrosis factor alpha (TNF-alpha) and melphalan after isolated limb perfusion (ILP) have been presented. We found a significant sixfold increase in melphalan tumour tissue concentration after ILP when TNF-alpha was added to the perfusate, which provides a straightforward explanation for the observed synergism between melphalan and TNF-alpha in ILP.

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