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Prevention and Control of Zika as a Mosquito-Borne and Sexually Transmitted Disease: A Mathematical Modeling Analysis

Daozhou Gao, Yijun Lou, Daihai He and 4 more

Scientific Reports · 2016 · CC BY

Abstract

The ongoing Zika virus (ZIKV) epidemic in the Americas poses a major global public health emergency. While ZIKV is transmitted from human to human by bites of Aedes mosquitoes, recent evidence indicates that ZIKV can also be transmitted via sexual contact with cases of sexually transmitted ZIKV reported in Argentina, Canada, Chile, France, Italy, New Zealand, Peru, Portugal, and the USA. Yet, the role of sexual transmission on the spread and control of ZIKV infection is not well-understood. We introduce a mathematical model to investigate the impact of mosquito-borne and sexual transmission on the spread and control of ZIKV and calibrate the model to ZIKV epidemic data from Brazil, Colombia, and El Salvador. Parameter estimates yielded a basic reproduction number "Equation missing" 0 = 2.055 (95% CI: 0.523–6.300), in which the percentage contribution of sexual transmission is 3.044% (95% CI: 0.123–45.73). Our sensitivity analyses indicate that "Equation missing" 0 is most sensitive to the biting rate and mortality rate of mosquitoes while sexual transmission increases the risk of infection and epidemic size and prolongs the outbreak. Prevention and control efforts against ZIKV should target both the mosquito-borne and sexual transmission routes.

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All 44 references

Cited by papers we hold 5

Estimation of mosquito-borne and sexual transmission of Zika virus in Australia: Risks to blood transfusion safety. · 2020
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Analysis of Zika virus dynamics with sexual transmission route using multiple optimal controls · 2020
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Prior dengue virus infection and risk of Zika: A pediatric cohort in Nicaragua · 2019
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Sexual transmission of Zika virus and other flaviviruses: A living systematic review · 2018
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Epidemiological and ecological determinants of Zika virus transmission in an urban setting · 2017
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