Angiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus

Abstract

Respiratory syncytial virus (RSV) infection is a major cause of severe lower respiratory illness in infants and young children, but the underlying mechanisms responsible for viral pathogenesis have not been fully elucidated. To date, no drugs or vaccines have been employed to improve clinical outcomes for RSV-infected patients. In this paper, we report that angiotensin-converting enzyme-2 (ACE2) protected against severe lung injury induced by RSV infection in an experimental mouse model and in pediatric patients. Moreover, ACE2 deficiency aggravated RSV-associated disease pathogenesis, mainly by its action on the angiotensin II type 1 receptor (AT1R). Furthermore, administration of a recombinant ACE2 protein alleviated the severity of RSV-induced lung injury. These findings demonstrate that ACE2 plays a critical role in preventing RSV-induced lung injury and suggest that ACE2 is a promising potential therapeutic target in the management of RSV-induced lung disease.

Cited by papers we hold 10

• Genetic Dissection of the Regulatory Mechanisms of Ace2 in the Infected Mouse Lung · 2021
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• Risk of SARS-CoV-2 infection and COVID-19 prognosis with the use of renin–angiotensin–aldosterone system (RAAS) inhibitors: a systematic review · 2021
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• Renin-Angiotensin System and Coronavirus Disease 2019: A Narrative Review · 2020
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• Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract · 2020
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• Repurposing existing drugs for COVID-19: an endocrinology perspective · 2020
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• Angiotensin‐converting enzyme 2 ( ACE2 ), SARS‐CoV ‐2 and the pathophysiology of coronavirus disease 2019 ( COVID ‐19) · 2020
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• Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig · 2020
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• ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19 · 2020
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• A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome · 2017
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• Angiotensin-converting enzyme 2 prevents lipopolysaccharide-induced rat acute lung injury via suppressing the ERK1/2 and NF-κB signaling pathways · 2016
  Corrected

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