Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury

Abstract

Since March 2013, the emergence of an avian-origin influenza A (H7N9) virus has raised concern in China. Although most infections resulted in respiratory illness, some severe cases resulted in acute respiratory distress syndrome (ARDS), which is a severe form of acute lung injury (ALI) that further contributes to morbidity. To date, no effective drugs that improve the clinical outcome of influenza A (H7N9) virus-infected patients have been identified. Angiotensin-converting enzyme (ACE) and ACE2 are involved in several pathologies such as cardiovascular functions, renal disease and acute lung injury. In the current study, we report that ACE2 could mediate the severe acute lung injury induced by influenza A (H7N9) virus infection in an experimental mouse model. Moreover, ACE2 deficiency worsened the disease pathogenesis markedly, mainly by targeting the angiotensin II type 1 receptor (AT1). The current findings demonstrate that ACE2 plays a critical role in influenza A (H7N9) virus-induced acute lung injury and suggest that might be a useful potential therapeutic target for future influenza A (H7N9) outbreaks.

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• Genetic Dissection of the Regulatory Mechanisms of Ace2 in the Infected Mouse Lung · 2021
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• Risk of SARS-CoV-2 infection and COVID-19 prognosis with the use of renin–angiotensin–aldosterone system (RAAS) inhibitors: a systematic review · 2021
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• Virus Infections and Host Metabolism—Can We Manage the Interactions? · 2021
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• COVID-19 Infection and Circulating ACE2 Levels: Protective Role in Women and Children · 2020
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• Individual variation of the SARS‐CoV‐2 receptor ACE2 gene expression and regulation · 2020
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• Renin-angiotensin system inhibitors improve the clinical outcomes of COVID-19 patients with hypertension · 2020
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• Angiotensin-converting enzyme 2 prevents lipopolysaccharide-induced rat acute lung injury via suppressing the ERK1/2 and NF-κB signaling pathways · 2016
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