Hybrid Capture II-based human papillomavirus detection, a sensitive test to detect in routine high-grade cervical lesions: a preliminary study on 1518 women

Abstract

Hybrid Capture II (HC-II) is a commercial human papillomavirus (HPV) detection test designed to detect 18 HPV types divided into high-risk and low-risk groups. We have tested 1647 scrapes from 1518 unselected women attending routine cytological screening by this assay for the detection of histologically proven high-grade lesions. The reliability of this test was also evaluated on 117 fresh cone biopsy samples. HPV DNA has been detected in 400 scrapes (24.3%), 296 containing a high-risk HPV (18.0%). All the smears evocative of high-grade lesions were positive for high-risk HPV, and high-risk HPV were detected in all the 34 cases presenting a histologically proven high-grade lesion and in 68 (97.1%) of the 70 cone biopsy samples showing a high-grade lesion or an invasive carcinoma. Thus, the sensitivity was superior to the sensitivity of cytology (85.3%). Nevertheless, the quantitative approach provided by the HC-II assay for the assessment of the viral load could not clearly distinguish among cases with or without high-grade lesions. Thus this assay is recommended for the screening of high-grade lesions on a large scale, in association with classic cytology.

References 21

1. 1.

   Bosch F. X., Manos M. M., Muñoz N., Sherman M., Jansen A. M., Peto J., Schiffman M. H., Moreno V., Kurman R., Shah K. V. Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. International biological study on cervical cancer (IBSCC) Study Group. J Natl Cancer Inst. 1995;87(11):796-802.

   Not in our library10.1093/jnci/87.11.796

2. 2.

   Clavel C., Bory J. P., Rihet S., Masure M., Duval-Binninger I., Putaud I., Lorenzato M., Quereux C., Birembaut P. Comparative analysis of human papillomavirus detection by hybrid capture assay and routine cytologic screening to detect high-grade cervical lesions. Int J Cancer. 1998;75(4):525-528.

   Not in our library10.1002/(sici)1097-0215(19980209)75:4<525::aid-ijc6>3.0.co;2-v

3. 3.

   Clavel C., Masure M., Putaud I., Thomas K., Bory J. P., Gabriel R., Quereux C., Birembaut P. Hybrid capture II, a new sensitive test for human papillomavirus detection. Comparison with hybrid capture I and PCR results in cervical lesions. J Clin Pathol. 1998;51(10):737-740.

   Not in our library10.1136/jcp.51.10.737

4. 4.

   Cox J. T., Lorincz A. T., Schiffman M. H., Sherman M. E., Cullen A., Kurman R. J. Human papillomavirus testing by hybrid capture appears to be useful in triaging women with a cytologic diagnosis of atypical squamous cells of undetermined significance. Am J Obstet Gynecol. 1995;172(3):946-954.

   Not in our library10.1016/0002-9378(95)90026-8

5. 5.
   Type-specific human papillomavirus DNA in abnormal smears as a predictor of high-grade cervical intraepithelial neoplasia · 1994

   No notice
6. 6.

   Diagnostic and therapeutic technology assessment. Human papillomavirus DNA testing in the management of cervical neoplasia. JAMA. 1993;270(24):2975-2981.

   Not in our library

7. 7.

   Farthing A., Masterson P., Mason W. P., Vousden K. H. Human papillomavirus detection by hybrid capture and its possible clinical use. J Clin Pathol. 1994;47(7):649-652.

   Not in our library10.1136/jcp.47.7.649

8. 8.

   Gaarenstroom K.N., Melkert P., Walboomers J.M.M., Van Den Brule A.J.C., Van Bommel P.F.J., Meyer C.J.L.M., Voorhorst F.J., Kenemans P., Helmerhorst Th.J.M. Human papillomavirus DNA and genotypes: prognostic factors for progression of cervical intraepithelial neoplasia. Int J Gynecol Cancer. 1994;4(2):73-78.

   Not in our library10.1046/j.1525-1438.1994.04020073.x

9. 9.

   Hatch K. D., Schneider A., Abdel-Nour M. W. An evaluation of human papillomavirus testing for intermediate- and high-risk types as triage before colposcopy. Am J Obstet Gynecol. 1995;172(4 Pt 1):1150-1157.

   Not in our library10.1016/0002-9378(95)91473-0

10. 10.

    Ho G. Y., Burk R. D., Klein S., Kadish A. S., Chang C. J., Palan P., Basu J., Tachezy R., Lewis R., Romney S. Persistent genital human papillomavirus infection as a risk factor for persistent cervical dysplasia. J Natl Cancer Inst. 1995;87(18):1365-1371.

    Not in our library10.1093/jnci/87.18.1365

11. 11.

    Kaufman R. H., Adam E., Icenogle J., Lawson H., Lee N., Reeves K. O., Irwin J., Simon T., Press M., Uhler R. Relevance of human papillomavirus screening in management of cervical intraepithelial neoplasia. Am J Obstet Gynecol. 1997;176(1 Pt 1):87-92.

    Not in our library10.1016/s0002-9378(97)80017-8

12. 12.

    Koutsky L. A., Holmes K. K., Critchlow C. W., Stevens C. E., Paavonen J., Beckmann A. M., DeRouen T. A., Galloway D. A., Vernon D., Kiviat N. B. A cohort study of the risk of cervical intraepithelial neoplasia grade 2 or 3 in relation to papillomavirus infection. N Engl J Med. 1992;327(18):1272-1278.

    Not in our library10.1056/nejm199210293271804

13. 13.

    Lorincz A. T., Reid R., Jenson A. B., Greenberg M. D., Lancaster W., Kurman R. J. Human papillomavirus infection of the cervix: relative risk associations of 15 common anogenital types. Obstet Gynecol. 1992;79(3):328-337.

    Not in our library10.1097/00006250-199203000-00002

14. 14.

    Remmink A. J., Walboomers J. M., Helmerhorst T. J., Voorhorst F. J., Rozendaal L., Risse E. K., Meijer C. J., Kenemans P. The presence of persistent high-risk HPV genotypes in dysplastic cervical lesions is associated with progressive disease: natural history up to 36 months. Int J Cancer. 1995;61(3):306-311.

    Not in our library10.1002/ijc.2910610305

15. 15.

    Richart R. M., Wright T. C. Controversies in the management of low-grade cervical intraepithelial neoplasia. Cancer. 1993;71(4 Suppl):1413-1421.

    Not in our library10.1002/cncr.2820710406

16. 16.

    Rozendaal L., Walboomers J. M., van der Linden J. C., Voorhorst F. J., Kenemans P., Helmerhorst T. J., van Ballegooijen M., Meijer C. J. PCR-based high-risk HPV test in cervical cancer screening gives objective risk assessment of women with cytomorphologically normal cervical smears. Int J Cancer. 1996;68(6):766-769.

    Not in our library10.1002/(sici)1097-0215(19961211)68:6<766::aid-ijc13>3.0.co;2-z

17. 17.

    Schiffman M. H., Kiviat N. B., Burk R. D., Shah K. V., Daniel R. W., Lewis R., Kuypers J., Manos M. M., Scott D. R., Sherman M. E. Accuracy and interlaboratory reliability of human papillomavirus DNA testing by hybrid capture. J Clin Microbiol. 1995;33(3):545-550.

    Not in our library10.1128/jcm.33.3.545-550.1995

18. 18.

    Sun X. W., Ferenczy A., Johnson D., Koulos J. P., Lungu O., Richart R. M., Wright T. C. Evaluation of the Hybrid Capture human papillomavirus deoxyribonucleic acid detection test. Am J Obstet Gynecol. 1995;173(5):1432-1437.

    Not in our library10.1016/0002-9378(95)90629-0

19. 19.

    Van Den Brule A. J., Walboomers J. M., Du Maine M., Kenemans P., Meijer C. J. Difference in prevalence of human papillomavirus genotypes in cytomorphologically normal cervical smears is associated with a history of cervical intraepithelial neoplasia. Int J Cancer. 1991;48(3):404-408.

    Not in our library10.1002/ijc.2910480317

20. 20.

    Wright T. C., Lorincz A., Ferris D. G., Richart R. M., Ferenczy A., Mielzynska I., Borgatta L. Reflex human papillomavirus deoxyribonucleic acid testing in women with abnormal Papanicolaou smears. Am J Obstet Gynecol. 1998;178(5):962-966.

    Not in our library10.1016/s0002-9378(98)70531-9

21. 21.

    zur Hausen H. Molecular pathogenesis of cancer of the cervix and its causation by specific human papillomavirus types. Curr Top Microbiol Immunol. 1994;186:131-156.

    Not in our library10.1007/978-3-642-78487-3_8

Cited by papers we hold 2

• Oropharyngeal Cancer Epidemic and Human Papillomavirus · 2010
  No notice
• Human papillomavirus testing in primary screening for the detection of high-grade cervical lesions: a study of 7932 women · 2001
  No notice

Reads

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.