Stimulation of tumour growth by wound-derived growth factors

Abstract

The goal of this work was to determine the molecular basis for the induction of tumour vascularization and progression by injury. Magnetic resonance imaging (MRI) studies demonstrated that administration of wound fluid derived from cutaneous injuries in pigs reduced the lag for vascularization and initiation of growth of C6 glioma spheroids, implanted in nude mice, and accelerated tumour doubling time. The former effect can be attributed to the angiogenic capacity of wound fluid as detected in vivo by MRI, and in vitro in promoting endothelial cell proliferation. The latter effect, namely the induced rate of tumour growth, is consistent with the angiogenic activity of wound fluid as well as with the finding that wound fluid was directly mitogenic to the tumour cells, and accelerated growth of C6 glioma in spheroid culture. Of the multiple growth factors present in wound fluid, two key factors, heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF) and platelet-derived growth factor (PDGF), were identified as the dominant mitogens for C6 glioma, and inhibition of their activity using specific neutralizing antibodies suppressed the mitogenic effect of wound fluid on DNA synthesis in C6 glioma. This study suggests that the stimulatory effect of injury on tumour progression can possibly be attenuated by therapeutic targeting directed against a limited number of specific growth factors.

References 24

1. 1.

   Abramovitch R., Frenkiel D., Neeman M. Analysis of subcutaneous angiogenesis by gradient echo magnetic resonance imaging. Magn Reson Med. 1998;39(5):813-824.

   Not in our library10.1002/mrm.1910390519

2. 2.

   Abramovitch R., Marikovsky M., Meir G., Neeman M. Stimulation of tumour angiogenesis by proximal wounds: spatial and temporal analysis by MRI. Br J Cancer. 1998;77(3):440-447.

   Not in our library10.1038/bjc.1998.70

3. 3.

   Abramovitch R., Meir G., Neeman M. Neovascularization induced growth of implanted C6 glioma multicellular spheroids: magnetic resonance microimaging. Cancer Res. 1995;55(9):1956-1962.

   Not in our library

4. 4.

   Abramovitch R., Neeman M., Reich R., Stein I., Keshet E., Abraham J., Solomon A., Marikovsky M. Intercellular communication between vascular smooth muscle and endothelial cells mediated by heparin-binding epidermal growth factor-like growth factor and vascular endothelial growth factor. FEBS Lett. 1998;425(3):441-447.

   Not in our library10.1016/s0014-5793(98)00283-x

5. 5.

   Bogden A. E., Moreau J. P., Eden P. A. Proliferative response of human and animal tumours to surgical wounding of normal tissues: onset, duration and inhibition. Br J Cancer. 1997;75(7):1021-1027.

   Not in our library10.1038/bjc.1997.175

6. 6.

   Deelman H. T. THE PART PLAYED BY INJURY AND REPAIR IN THE DEVELOPMENT OF CANCER. Br Med J. 1927;1(3462):872-872.

   Not in our library10.1136/bmj.1.3462.872

7. 7.

   Dvorak H. F., Brown L. F., Detmar M., Dvorak A. M. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol. 1995;146(5):1029-1039.

   Not in our library

8. 8.

   Frank S., Hübner G., Breier G., Longaker M. T., Greenhalgh D. G., Werner S. Regulation of vascular endothelial growth factor expression in cultured keratinocytes. Implications for normal and impaired wound healing. J Biol Chem. 1995;270(21):12607-12613.

   Not in our library10.1074/jbc.270.21.12607

9. 9.

   Higashiyama S., Abraham J. A., Miller J., Fiddes J. C., Klagsbrun M. A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. Science. 1991;251(4996):936-939.

   Not in our library10.1126/science.1840698

10. 10.

    Libermann T. A., Nusbaum H. R., Razon N., Kris R., Lax I., Soreq H., Whittle N., Waterfield M. D., Ullrich A., Schlessinger J. Amplification and overexpression of the EGF receptor gene in primary human glioblastomas. J Cell Sci Suppl. 1985;3:161-172.

    Not in our library10.1242/jcs.1985.supplement_3.16

11. 11.

    Lynch S. E. Interactions of growth factors in tissue repair. Prog Clin Biol Res. 1991;365:341-357.

    Not in our library

12. 12.

    Marikovsky M., Breuing K., Liu P. Y., Eriksson E., Higashiyama S., Farber P., Abraham J., Klagsbrun M. Appearance of heparin-binding EGF-like growth factor in wound fluid as a response to injury. Proc Natl Acad Sci U S A. 1993;90(9):3889-3893.

    Not in our library10.1073/pnas.90.9.3889

13. 13.

    Marikovsky M., Vogt P., Eriksson E., Rubin J. S., Taylor W. G., Joachim S., Klagsbrun M. Wound fluid-derived heparin-binding EGF-like growth factor (HB-EGF) is synergistic with insulin-like growth factor-I for Balb/MK keratinocyte proliferation. J Invest Dermatol. 1996;106(4):616-621.

    Not in our library10.1111/1523-1747.ep12345413

14. 14.

    Moulin V. Growth factors in skin wound healing. Eur J Cell Biol. 1995;68(1):1-7.

    Not in our library

15. 15.

    Murthy M. S., Summaria L. J., Miller R. J., Wyse T. B., Goldschmidt R. A., Scanlon E. F. Inhibition of tumor implantation at sites of trauma by plasminogen activators. Cancer. 1991;68(8):1724-1730.

    Not in our library10.1002/1097-0142(19911015)68:8<1724::aid-cncr2820680813>3.0.co;2-w

16. 16.

    Murthy S. M., Goldschmidt R. A., Rao L. N., Ammirati M., Buchmann T., Scanlon E. F. The influence of surgical trauma on experimental metastasis. Cancer. 1989;64(10):2035-2044.

    Not in our library10.1002/1097-0142(19891115)64:10<2035::aid-cncr2820641012>3.0.co;2-l

17. 17.

    O'Reilly M. S., Holmgren L., Chen C., Folkman J. Angiostatin induces and sustains dormancy of human primary tumors in mice. Nat Med. 1996;2(6):689-692.

    Not in our library10.1038/nm0696-689

18. 18.

    O'Reilly M. S., Holmgren L., Shing Y., Chen C., Rosenthal R. A., Moses M., Lane W. S., Cao Y., Sage E. H., Folkman J. Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell. 1994;79(2):315-328.

    Not in our library10.1016/0092-8674(94)90200-3

19. 19.

    Pedersen P. H., Ness G. O., Engebraaten O., Bjerkvig R., Lillehaug J. R., Laerum O. D. Heterogeneous response to the growth factors [EGF, PDGF (bb), TGF-alpha, bFGF, IL-2] on glioma spheroid growth, migration and invasion. Int J Cancer. 1994;56(2):255-261.

    Not in our library10.1002/ijc.2910560219

20. 20.

    Peoples G. E., Blotnick S., Takahashi K., Freeman M. R., Klagsbrun M., Eberlein T. J. T lymphocytes that infiltrate tumors and atherosclerotic plaques produce heparin-binding epidermal growth factor-like growth factor and basic fibroblast growth factor: a potential pathologic role. Proc Natl Acad Sci U S A. 1995;92(14):6547-6551.

    Not in our library10.1073/pnas.92.14.6547

21. 21.

    Pollack I. F., Randall M. S., Kristofik M. P., Kelly R. H., Selker R. G., Vertosick F. T. Response of low-passage human malignant gliomas in vitro to stimulation and selective inhibition of growth factor-mediated pathways. J Neurosurg. 1991;75(2):284-293.

    Not in our library10.3171/jns.1991.75.2.0284

22. 22.

    Schiffenbauer Y. S., Abramovitch R., Meir G., Nevo N., Holzinger M., Itin A., Keshet E., Neeman M. Loss of ovarian function promotes angiogenesis in human ovarian carcinoma. Proc Natl Acad Sci U S A. 1997;94(24):13203-13208.

    Not in our library10.1073/pnas.94.24.13203

23. 23.

    Strawn L. M., Mann E., Elliger S. S., Chu L. M., Germain L. L., Niederfellner G., Ullrich A., Shawver L. K. Inhibition of glioma cell growth by a truncated platelet-derived growth factor-beta receptor. J Biol Chem. 1994;269(33):21215-21222.

    Not in our library

24. 24.

    Tsai J. C., Goldman C. K., Gillespie G. Y. Vascular endothelial growth factor in human glioma cell lines: induced secretion by EGF, PDGF-BB, and bFGF. J Neurosurg. 1995;82(5):864-873.

    Not in our library10.3171/jns.1995.82.5.0864

Cited by papers we hold 4

• Long-term Oncologic Outcome of Postoperative Complications After Colorectal Cancer Surgery · 2020
  Not checked
• Potential impact of invasive surgical procedures on primary tumor growth and metastasis · 2018
  No notice
• Postoperative wound complications and systemic recurrence in breast cancer · 2007
  No notice
• The systemic inflammatory response, weight loss, performance status and survival in patients with inoperable non-small cell lung cancer · 2002
  No notice

Reads

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.