Quantitative characterization of recombinase-based digitizer circuits enables predictable amplification of biological signals
Katherine A. Kiwimagi, Justin H. Letendre, Benjamin H. Weinberg and 7 more
Communications Biology · 2021
doi:10.1038/s42003-021-02325-5 (opens in a new tab)
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Abstract
Kiwimagi & Letendre et al. present a workflow to quantitatively define recombinase-based digitizer and predict responses to different input signals. With a mechanistic/phenotypic model that can predict circuit performance, they generate a synthetic cell-cell communication device that amplifies a synNotch output signal.
Abstract licence: CC BY-NC-ND
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