IKKε isoform switching governs the immune response against EV71 infection
Ya-Ling Chang, Yu-Wen Liao, Min-Hsuan Chen and 4 more
Communications Biology · 2021
doi:10.1038/s42003-021-02187-x (opens in a new tab)
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Abstract
Chang et al. show that Enterovirus 71 (EV71) infection upregulates IKKε isoform 2 (IKKε v2), which in turn activates interferon regulatory factor 7 (IRF7). This study suggests that host cells trigger IKKε isoform switching to increase the production of interferon against EV71 infection, providing a potential strategy for boosting host’s antiviral defense.
Abstract licence: CC BY-NC-ND
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