A follicular regulatory Innate Lymphoid Cell population impairs interactions between germinal center Tfh and B cells
Margaret H. O’Connor, Roshell Muir, Marita Chakhtoura and 11 more
Communications Biology · 2021
doi:10.1038/s42003-021-02079-0 (opens in a new tab)
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Abstract
Margaret O’Connor et al. report a new Innate Lymphoid Cell population in human tonsils and lymph nodes that inhibit the functional interaction of follicular helper T cells and germinal center B cells. They show that this cell population is expanded under chronic HIV infection and results in decreased antibody production, suggesting a potential role for these cells in diseases with dysregulated immune responses.
Abstract licence: CC BY-NC-ND
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