Insulin-like 3 affects zebrafish spermatogenic cells directly and via Sertoli cells
Diego Crespo, Luiz H. C. Assis, Yu Ting Zhang and 10 more
Communications Biology · 2021
doi:10.1038/s42003-021-01708-y (opens in a new tab)
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Abstract
Insulin-like 3 (Insl3) belongs to a class of peptide hormones that are expressed in the Leydig cells and, in zebrafish, under the control of folliclestimulating hormone (Fsh) in the pituitary. Using insl3 knockout zebrafish, the authors found that Insl3 regulates spermatogonia differentiation and apoptosis via the Pparg and retinoic acid pathways.
Abstract licence: CC BY-NC-ND
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