Changes in gut microbiota in the acute phase after spinal cord injury correlate with severity of the lesion

After spinal cord injury (SCI), patients face many physical and psychological issues including intestinal dysfunction and comorbidities, strongly affecting quality of life. The gut microbiota has recently been suggested to influence the course of the disease in these patients. However, to date only two studies have profiled the gut microbiota in SCI patients, months after a traumatic injury. Here we characterized the gut microbiota in a large Italian SCI population, within a short time from a not only traumatic injury. Feces were collected within the first week at the rehabilitation center (no later than 60 days after SCI), and profiled by 16S rRNA gene-based next-generation sequencing. Microbial profiles were compared to those publicly available of healthy age- and gender-matched Italians, and correlated to patient metadata, including type of SCI, spinal unit location, nutrition and concomitant antibiotic therapies. The gut microbiota of SCI patients shows distinct dysbiotic signatures, i.e. increase in potentially pathogenic, pro-inflammatory and mucus-degrading bacteria, and depletion of short-chain fatty acid producers. While robust to most host variables, such dysbiosis varies by lesion level and completeness, with the most neurologically impaired patients showing an even more unbalanced microbial profile. The SCI-related gut microbiome dysbiosis is very likely secondary to injury and closely related to the degree of completeness and severity of the lesion, regardless of etiology and time interval. This microbial layout could variously contribute to increased gut permeability and inflammation, potentially predisposing patients to the onset of severe comorbidities.

Abstract licence: CC BY-NC-ND

1. 27.

   PANDAseq: paired-end assembler for illumina sequences · 2012

2. 34.

   Intestinal Microbiota in Patients with Spinal Cord Injury · 2016

3. 38.

   An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis · 2016

4. 43.

   Alterations of the human gut microbiome in multiple sclerosis · 2016

5. 46.

   Extreme Dysbiosis of the Microbiome in Critical Illness · 2016

6. 50.

   Dysbiosis and compositional alterations with aging in the gut microbiota of patients with heart failure · 2017

7. 55.

   Meta-analysis of gut microbiome studies identifies disease-specific and shared responses · 2017

8. 59.

   Changes of Colonic Bacterial Composition in Parkinson’s Disease and Other Neurodegenerative Diseases · 2018

9. 78.

   The Integrative Human Microbiome Project · 2019

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