Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection

Abstract

Severe acute respiratory syndrome-coronavirus (SARS-CoV) and SARS-like coronavirus are a potential threat to global health. However, reviews of the long-term effects of clinical treatments in SARS patients are lacking. Here a total of 25 recovered SARS patients were recruited 12 years after infection. Clinical questionnaire responses and examination findings indicated that the patients had experienced various diseases, including lung susceptibility to infections, tumors, cardiovascular disorders, and abnormal glucose metabolism. As compared to healthy controls, metabolomic analyses identified significant differences in the serum metabolomes of SARS survivors. The most significant metabolic disruptions were the comprehensive increase of phosphatidylinositol and lysophospha tidylinositol levels in recovered SARS patients, which coincided with the effect of methylprednisolone administration investigated further in the steroid treated non-SARS patients with severe pneumonia. These results suggested that high-dose pulses of methylprednisolone might cause long-term systemic damage associated with serum metabolic alterations. The present study provided information for an improved understanding of coronavirus-associated pathologies, which might permit further optimization of clinical treatments.

Cited by papers we hold 8

• Metabolic Alterations in SARS-CoV-2 Infection and Its Implication in Kidney Dysfunction · 2021
  Not checked
• Unraveling the Mystery Surrounding Post-Acute Sequelae of COVID-19 · 2021
  No notice
• Plasma Markers of Disrupted Gut Permeability in Severe COVID-19 Patients · 2021
  Corrected
• Large-Scale Plasma Analysis Revealed New Mechanisms and Molecules Associated with the Host Response to SARS-CoV-2 · 2020
  No notice
• Short- and potential long-term adverse health outcomes of COVID-19: a rapid review · 2020
  No notice
• Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2 · 2020
  No notice
• The Role of Lipid Metabolism in COVID-19 Virus Infection and as a Drug Target · 2020
  No notice
• Comorbid Chronic Diseases and Acute Organ Injuries Are Strongly Correlated with Disease Severity and Mortality among COVID-19 Patients: A Systemic Review and Meta-Analysis · 2020
  No notice

Reads

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.