No retraction, correction or concern found when last checked on Oct 17, 2026.
Multitask learning and benchmarking with clinical time series data
Hrayr Harutyunyan, Hrant Khachatrian, David C. Kale and 2 more
Scientific Data · 2019 · CC BY
Abstract
Health care is one of the most exciting frontiers in data mining and machine learning. Successful adoption of electronic health records (EHRs) created an explosion in digital clinical data available for analysis, but progress in machine learning for healthcare research has been difficult to measure because of the absence of publicly available benchmark data sets. To address this problem, we propose four clinical prediction benchmarks using data derived from the publicly available Medical Information Mart for Intensive Care (MIMIC-III) database. These tasks cover a range of clinical problems including modeling risk of mortality, forecasting length of stay, detecting physiologic decline, and phenotype classification. We propose strong linear and neural baselines for all four tasks and evaluate the effect of deep supervision, multitask training and data-specific architectural modifications on the performance of neural models.
Full text
Its licence does not allow us to show the full text. Read it at PubMed Central:
Read at PubMed CentralReferences 78
- 1.
Introduction to the HCUP National Inpatient Sample (NIS) 2012. (Agency for Healthcare Research and Quality, 2014).
Not in our library
- 2.
Henry, J., Pylypchuk, Y., Talisha Searcy, M. & Patel, V. Adoption of electronic health record systems among US non-federal acute care hospitals: 2008–2015. ONCData Brief35 (Office of the National Coordinator for Health Information Technology, Washington DC, USA, 2015).
Not in our library
- 3.
Bates DW, Saria S, Ohno-Machado L, Shah A, Escobar G. Big data in health care: using analytics to identify and manage high-risk and high-cost patients. Health Affairs. 2014;33:1123-1131.
Not in our library10.1377/hlthaff.2014.0041
- 4.
Zimmerman JE, Kramer AA, McNair DS, Malila FM. Acute physiology and chronic health evaluation (apache) iv: hospital mortality assessment for today’s critically ill patients. Crit. Care Med. 2006;34:1297-1310.
Not in our library10.1097/01.ccm.0000215112.84523.f0
- 5.
Williams, B. et al. National Early Warning Score (NEWS): Standardising the assessment of acute-illness severity in the NHS. (London: The Royal College of Physicians, 2012).
Not in our library
- 6.
Dahl D, et al. The high cost of low-acuity icu outliers. Journal of Healthcare Management. 2012;57:421-433.
Not in our library10.1097/00115514-201211000-00009
- 7.
Saria S, Goldenberg A. Subtyping: What it is and its role in precision medicine. IEEE Intelligent Systems. 2015;30:70-75.
Not in our library10.1109/mis.2015.60
- 8.
Iserson KV, Moskop JC. Triage in medicine, part i: concept, history, and types. Ann. Emerg. Med. 2007;49:275-281.
Not in our library10.1016/j.annemergmed.2006.05.019
- 9.
Apgar V. A proposal for a new method of evaluation of the newborn. Curr. Res. Anesth. Analg. 1952;32:260-267.
Not in our library
- 10.
Ferrucci D, Levas A, Bagchi S, Gondek D, Mueller ET. Watson: beyond jeopardy! Artificial Intelligence. 2013;199:93-105.
Not in our library10.1016/j.artint.2012.06.009
- 11.
Silver D, et al. Mastering the game of go with deep neural networks and tree search. Nature. 2016;529:484-489.
Not in our library10.1038/nature16961
- 12.
Caballero Barajas, K. L. & Akella, R. Dynamically modeling patient’s health state from electronic medical records: A time series approach. In Proceedings of the 21th ACM SIGKDD International Conference on Knowledge Discovery and Data Mining, 69–78 (ACM, Sydney, Australia, 2015).
Not in our library
- 13.
Ghassemi, M. et al. A multivariate timeseries modeling approach to severity of illness assessment and forecasting in icu with sparse, heterogeneous clinical data. In Proceedings of the Twenty-Ninth AAAI Conference on Artificial Intelligence, 446–453 (AAAI Press, Austin, Texas, 2015).
Not in our library
- 14.
Luo, Y., Xin, Y., Joshi, R., Celi, L. & Szolovits, P. Predicting icu mortality risk by grouping temporal trends from a multivariate panel of physiologic measurements. In Proceedings of the Thirtieth AAAI Conference on Artificial Intelligence, 42–50 (AAAI Press, Phoenix, Arizona, 2016).
Not in our library
- 15.
Lee J, Maslove DM. Customization of a severity of illness score using local electronic medical record data. Journal of intensive care medicine. 2017;32:38-47.
Not in our library10.1177/0885066615585951
- 16.
Johnson, A., Pollard, T. & Mark, R. Reproducibility in critical care: a mortality prediction case study. In Proceedings of the 2nd Machine Learning for Healthcare Conference, vol. 68, 361–376 (PMLR, Boston, Massachusetts, 2017).
Not in our library
- 17.
Quinn JA, Williams CK, McIntosh N. Factorial switching linear dynamical systems applied to physiological condition monitoring. IEEE Trans. Pattern Anal. Mach. Intell. 2009;31:1537-1551.
Not in our library10.1109/tpami.2008.191
- 18.
Laxmisan A, et al. The multitasking clinician: Decision-making and cognitive demand during and after team handoffs in emergency care. Int. J. Med. Inform. 2007;76:801-811.
Not in our library10.1016/j.ijmedinf.2006.09.019
- 19.
Horn SD, et al. The relationship between severity of illness and hospital length of stay and mortality. Med. Care. 1991;29:305-317.
Not in our library10.1097/00005650-199104000-00001
- 20.
- 21.
Laboratory For Computational Physiology, M. I. T. The MIMIC-III clinical database. PhysioNet., 10.13026/C2XW26 (2015).
Not in our library
- 22.
Harutyunyan H, et al. MIMIC-III benchmark repository. Zenodo. 2018.
Not in our library10.5281/zenodo.1306527
- 23.
Caruana, R., Baluja, S. & Mitchell, T. Using the future to “sort out” the present: Rankprop and multitask learning for medical risk evaluation. In Advances in Neural Information Processing Systems8, 959–965 (MIT Press, Denver, Colorado, 1996).
Not in our library
- 24.
Clermont G, Angus DC, DiRusso SM, Griffin M, Linde-Zwirble WT. Predicting hospital mortality for patients in the intensive care unit: a comparison of artificial neural networks with logistic fmultion models. Crit. Care Med. 2001;29:291-296.
Not in our library10.1097/00003246-200102000-00012
- 25.
Celi LA, et al. A database-driven decision support system: customized mortality prediction. J. Pers. Med. 2012;2:138-148.
Not in our library10.3390/jpm2040138
- 26.
- 27.
Grigsby J, Kooken R, Hershberger J. Simulated neural networks to predict outcomes, costs, and length of stay among orthopedic rehabilitation patients. Arch. Phys. Med. Rehabil. 1994;75:1077-1081.
Not in our library10.1016/0003-9993(94)90081-7
- 28.
Mobley BA, Leasure R, Davidson L. Artificial neural network predictions of lengths of stay on a post-coronary care unit. Heart & Lung: The Journal of Acute and Critical Care. 1995;24:251-256.
Not in our library10.1016/s0147-9563(05)80045-7
- 29.
Buchman TG, Kubos KL, Seidler AJ, Siegforth MJ. A comparison of statistical and connectionist models for the prediction of chronicity in a surgical intensive care unit. Crit. Care Med. 1994;22:750-762.
Not in our library10.1097/00003246-199405000-00008
- 30.
Yousefi, S., Song, C., Nauata, N. & Cooper, L. Learning genomic representations to predict clinical outcomes in cancer. Preprint at, https://arxiv.org/abs/1609.08663 (2016).
Not in our library
- 31.
Ranganath, R., Perotte, A., Elhadad, N. & Blei, D. Deep survival analysis. In Proceedings of the 1st Machine Learning for Healthcare Conference, vol. 56 (PMLR, Los Angeles, California, USA, 2016).
Not in our library
- 32.
- 33.
Che, Z., Kale, D., Li, W., Bahadori, M. T. & Liu, Y. Deep computational phenotyping. In Proceedings of the 21th ACM SIGKDD International Conference on Knowledge Discovery and Data Mining, 507–516 (ACM, Sydney, Australia, 2015).
Not in our library
- 34.
Choi, E., Bahadori, M. T., Schuetz, A., Stewart, W. F. & Sun, J. Doctor AI: Predicting clinical events via recurrent neural networks. In Proceedings of the 1st Machine Learning for Healthcare Conference, vol. 56 (PMLR, Los Angeles, California, USA, 2016).
Not in our library
- 35.
Razavian, N., Marcus, J. & Sontag, D. Multi-task prediction of disease onsets from longitudinal lab tests. In Proceedings of the 1st Machine Learning for Healthcare Conference, vol. 56 (PMLR, Los Angeles, California, USA, 2016).
Not in our library
- 36.
Lipton, Z. C., Kale, D. C., Elkan, C. & Wetzel, R. Learning to diagnose with LSTM recurrent neural networks. In International Conference on Learning Representations (San Juan, Puerto Rico, 2016).
Not in our library
- 37.
Ngufor, C., Upadhyaya, S., Murphree, D., Kor, D. & Pathak, J. Multi-task learning with selective cross-task transfer for predicting bleeding and other important patient outcomes. In IEEE International Conference on Data Science and Advanced Analytics (DSAA), 1–8 (IEEE, Paris, France, 2015).
Not in our library
- 38.
Collobert, R. & Weston, J. A unified architecture for natural language processing: Deep neural networks with multitask learning. In Proceedings of the 25th international conference on Machine learning, 160–167 (ACM, Helsinki, Finland, 2008).
Not in our library
- 39.
Gupta, P., Malhotra, P., Vig, L. & Shroff, G. Using features from pre-trained timenet for clinical predictions. In Proceedings of the 3rd International Workshop on Knowledge Discovery in Healthcare Data at IJCAI-ECAI, 38–44 (Stockholm, Sweden, 2018).
Not in our library
- 40.
Gupta, P., Malhotra, P., Vig, L. & Shroff, G. Transfer learning for clinical time series analysis using recurrent neural networks. In Machine Learning for Medicine and Healthcare Workshop at ACM KDD 2018 Conference (London, United Kingdom, 2018).
Not in our library
- 41.
Jin, M. et al. Improving hospital mortality prediction with medical named entities and multimodal learning. In Machine Learning for Health (ML4H) Workshop at NeurIPS (Montreal, Canada, 2018).
Not in our library
- 42.
Oh, J., Wang, J. & Wiens, J. Learning to exploit invariances in clinical time-series data using sequence transformer networks. In Proceedings of the 3rd Machine Learning for Healthcare Conference, vol. 85, 332–347 (PMLR, Palo Alto, California, USA, 2018).
Not in our library
- 43.
Malone, B., Garcia-Duran, A. & Niepert, M. Learning representations of missing data for predicting patient outcomes. Preprint at, https://arxiv.org/abs/1811.04752 (2018).
Not in our library
- 44.
Chang, C.-H., Mai, M. & Goldenberg, A. Dynamic measurement scheduling for adverse event forecasting using deep RL. In Machine Learning for Health (ML4H) Workshop at NeurIPS (Montreal, Canada, 2018).
Not in our library
- 45.
Xu, Y., Biswal, S., Deshpande, S. R., Maher, K. O. & Sun, J. Raim: Recurrent attentive and intensive model of multimodal patient monitoring data. In Proceedings of the 24th ACM SIGKDD International Conference on Knowledge Discovery & Data Mining, 2565–2573 (ACM, London, United Kingdom, 2018).
Not in our library
- 46.
Chung, I., Kim, S., Lee, J., Hwang, S. J. & Yang, E. Mixed effect composite RNN-GP: A personalized and reliable prediction model for healthcare. Preprint at, https://arxiv.org/abs/1806.01551 (2018).
Not in our library
- 47.
Bahadori, M. T. Spectral capsule networks. In International Conference on Learning Representations Workshop Track (New Orleans, Louisiana, USA, 2018).
Not in our library
- 48.
Rafi, P., Pakbin, A. & Pentyala, S. K. Interpretable deep learning framework for predicting all-cause 30-day ICU readmissions. Tech. Rep., (Texas A&M University, 2018).
Not in our library
- 49.
Song, H., Rajan, D., Thiagarajan, J. J. & Spanias, A. Attend and diagnose: Clinical time series analysis using attention models. In Proceedings of the Thirty-Second AAAI Conference on Artificial Intelligence (AAAI Press, New Orleans, Louisiana, USA, 2018).
Not in our library
- 50.
Purushotham S, Meng C, Che Z, Liu Y. Benchmarking deep learning models on large healthcare datasets. J. Biomed. Inform. 2018;83:112-134.
Not in our library10.1016/j.jbi.2018.04.007
- 51.
Le Gall J-R, et al. A simplified acute physiology score for icu patients. Crit. Care Med. 1984;12:975-977.
Not in our library10.1097/00003246-198411000-00012
- 52.
Silva, I., Moody, G., Scott, D. J., Celi, L. A. & Mark, R. G. Predicting in-hospital mortality of icu patients: The physionet/computing in cardiology challenge 2012. In 2012 Computing in Cardiology, 245–248 (IEEE, Krakow, Poland, 2012).
Not in our library
- 53.
Marlin, B. M., Kale, D. C., Khemani, R. G. & Wetzel, R. C. Unsupervised pattern discovery in electronic health care data using probabilistic clustering models. In Proceedings of the 2nd ACM SIGHIT International Health Informatics Symposium, 389–398 (ACM, Miami, Florida, 2012).
Not in our library
- 54.
Davis, J. & Goadrich, M. The relationship between precision-recall and roc curves. In Proceedings of the 23rd International Conference on Machine Learning, 233–240 (ACM, Pittsburgh, Pennsylvania, USA, 2006).
Not in our library
- 55.
Subbe C, Kruger M, Rutherford P, Gemmel L. Validation of a modified early warning score in medical admissions. Qjm. 2001;94:521-526.
Not in our library10.1093/qjmed/94.10.521
- 56.
Prytherch DR, Smith GB, Schmidt PE, Featherstone PI. Views – towards a national early warning score for detecting adult inpatient deterioration. Resuscitation. 2010;81:932-937.
Not in our library10.1016/j.resuscitation.2010.04.014
- 57.
Aleks, N. et al. Probabilistic detection of short events, with application to critical care monitoring. In Advances in Neural Information Processing Systems21, 49–56 (Curran Associates, Inc., Vancouver, Canada, 2009).
Not in our library
- 58.
Henry KE, Hager DN, Pronovost PJ, Saria S. A targeted real-time early warning score (trewscore) for septic shock. Sci. Transl. Med. 2015;7:299ra122-299ra122.
Not in our library10.1126/scitranslmed.aab3719
- 59.
Clifton, L., Clifton, D. A., Pimentel, M. A., Watkinson, P. J. & Tarassenko, L. Gaussian process regression in vital-sign early warning systems. In 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 6161–6164 (IEEE, San Diego, California, USA, 2012).
Not in our library10.1109/embc.2012.6347400
- 60.
Romano, P., Hussey P. & Ritley, D. Selecting quality and resource use measures: A decision guide for community quality collaboratives. (Agency for Healthcare Research and Quality, 2014).
Not in our library
- 61.
Higgins TL, et al. Early indicators of prolonged intensive care unit stay: Impact of illness severity, physician staffing, and pre–intensive care unit length of stay. Crit. Care Med. 2003;31:45-51.
Not in our library10.1097/00003246-200301000-00007
- 62.
Osler TM, et al. Predicting survival, length of stay, and cost in the surgical intensive care unit: Apache ii versus iciss. Journal of Trauma and Acute Care Surgery. 1998;45:234-238.
Not in our library10.1097/00005373-199808000-00006
- 63.
Paterson R, et al. Prediction of in-hospital mortality and length of stay using an early warning scoring system: clinical audit. Clinical Medicine. 2006;6:281-284.
Not in our library10.7861/clinmedicine.6-3-281
- 64.
Pofahl WE, Walczak SM, Rhone E, Izenberg SD. Use of an artificial neural network to predict length of stay in acute pancreatitis. The American Surgeon. 1998;64:868.
Not in our library
- 65.
Cohen J. A coefficient of agreement for nominal scales. Educational and Psychological Measurement. 1960;20:37-46.
Not in our library10.1177/001316446002000104
- 66.
Brennan RL, Prediger DJ. Coefficient kappa: Some uses, misuses, and alternatives. Educ. Psychol. Meas. 1981;41:687-699.
Not in our library10.1177/001316448104100307
- 67.
Oellrich A, et al. The digital revolution in phenotyping. Brief. Bioinform. 2015;17:819-830.
Not in our library10.1093/bib/bbv083
- 68.
Agarwal V, et al. Learning statistical models of phenotypes using noisy labeled training data. Journal of the American Medical Informatics Association. 2016;23:1166.
Not in our library10.1093/jamia/ocw028
- 69.
Halpern Y, Horng S, Choi Y, Sontag D. Electronic medical record phenotyping using the anchor and learn framework. Journal of the American Medical Informatics Association. 2016;23:731.
Not in our library10.1093/jamia/ocw011
- 70.
Ho, J. C., Ghosh, J. & Sun, J. Marble: High-throughput phenotyping from electronic health records via sparse nonnegative tensor factorization. In Proceedings of the 20th ACM SIGKDD International Conference on Knowledge Discovery and Data Mining, 115–124 (ACM, New York, New York, USA, 2014).
Not in our library
- 71.
Clinical Classifications Software (CCS) for ICD-9-CM fact sheet (Agency for Healthcare Research and Quality, 2012).
Not in our library
- 72.
Hochreiter S, Schmidhuber J. Long short-term memory. Neur. Comp. 1997;9:1735-1780.
Not in our library10.1162/neco.1997.9.8.1735
- 73.
Gers, F. A. & Schmidhuber, J. Recurrent nets that time and count. In Proceedings of the IEEE-INNS-ENNS International Joint Conference on Neural Networks, vol. 3, 189–194 (IEEE, Como, Italy, 2000).
Not in our library
- 74.
Lipton, Z. C., Kale, D. C. & Wetzel, R. Modeling missing data in clinical time series with rnns. In Proceedings of the 1st Machine Learning for Healthcare Conference, vol. 56 (PMLR, Los Angeles, California, USA, 2016).
Not in our library
- 75.
Kingma, D. & Ba, J. Adam: A method for stochastic optimization. Preprint at, https://arxiv.org/abs/1412.6980 (2014).
Not in our library
- 76.
Choi, E. et al. Retain: An interpretable predictive model for healthcare using reverse time attention mechanism. In Advances in Neural Information Processing Systems29, 3504–3512 (Curran Associates, Inc., Barcelona, Spain, 2016).
Not in our library
- 77.
- 78.
Rajpurkar, P. et al. CheXNet: Radiologist-level pneumonia detection on chest X-rays with deep learning. Preprint at, https://arxiv.org/abs/1711.05225 (2017).
Not in our library
Cited by papers we hold 7
- Bias in medical AI: Implications for clinical decision-making · 2024No notice
- A comparison of approaches to improve worst-case predictive model performance over patient subpopulations · 2022Not checked
- A systematic review of the prediction of hospital length of stay: Towards a unified framework · 2022No notice
- A New Hybrid Predictive Model to Predict the Early Mortality Risk in Intensive Care Units on a Highly Imbalanced Dataset · 2020Not checked
- Combining structured and unstructured data for predictive models: a deep learning approach · 2020No notice
- Deep learning and alternative learning strategies for retrospective real-world clinical data · 2019No notice
- Scalable and accurate deep learning with electronic health records · 2018No notice
Reads
Read by people on this page
None yet.
Checked or read by AI through naulon
None yet.
A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.
Are you an author?
Is this your paper?
Claim it to add your note and be paid when agents cite it. Free.