No retraction, correction or concern found when last checked on Nov 2, 2026.

Retrospective detection of asymptomatic monkeypox virus infections among male sexual health clinic attendees in Belgium

Irith De Baetselier, Christophe Van Dijck, Chris Kenyon and 41 more

Nature Medicine · 2022

doi:10.1038/s41591-022-02004-w

Abstract

The magnitude of the 2022 multi-country monkeypox virus (MPXV) outbreak has surpassed any preceding outbreak. It is unclear whether asymptomatic or otherwise undiagnosed infections are fuelling this epidemic. In this study, we aimed to assess whether undiagnosed infections occurred among men attending a Belgian sexual health clinic in May 2022. We retrospectively screened 224 samples collected for gonorrhea and chlamydia testing using an MPXV PCR assay and identified MPXV-DNA-positive samples from four men. At the time of sampling, one man had a painful rash, and three men had reported no symptoms. Upon clinical examination 21–37 days later, these three men were free of clinical signs, and they reported not having experienced any symptoms. Serology confirmed MPXV exposure in all three men, and MPXV was cultured from two cases. These findings show that certain cases of monkeypox remain undiagnosed and suggest that testing and quarantining of individuals reporting symptoms may not suffice to contain the outbreak.

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References 40

1.
This reference’s wording can’t be shown under the paper’s licence.
Not in our library
2.
This reference’s wording can’t be shown under the paper’s licence.
Not in our library
3.
This reference’s wording can’t be shown under the paper’s licence.
Not in our library
4.
This reference’s wording can’t be shown under the paper’s licence.
Not in our library
5.
This reference’s wording can’t be shown under the paper’s licence.
Not in our library
6.
This reference’s wording can’t be shown under the paper’s licence.
Not in our library
7.
This reference’s wording can’t be shown under the paper’s licence.
Not in our library
8.
This reference’s wording can’t be shown under the paper’s licence.
Not in our library
9.
This reference’s wording can’t be shown under the paper’s licence.
Not in our library
10.
This reference’s wording can’t be shown under the paper’s licence.
Not in our library
11.
This reference’s wording can’t be shown under the paper’s licence.
Not in our library
12.
This reference’s wording can’t be shown under the paper’s licence.
Not in our library
13.
This reference’s wording can’t be shown under the paper’s licence.
Not in our library
14.
This reference’s wording can’t be shown under the paper’s licence.
Not in our library
15.
This reference’s wording can’t be shown under the paper’s licence.
Not in our library
16.
SNP-sites: rapid efficient extraction of SNPs from multi-FASTA alignments · 2016
No notice
17.
This reference’s wording can’t be shown under the paper’s licence.
Not in our library
18.
Strain-level metagenomic assignment and compositional estimation for long reads with MetaMaps · 2019
No notice
19.
A systematic review of the epidemiology of human monkeypox outbreaks and implications for outbreak strategy · 2019
No notice
20.
This reference’s wording can’t be shown under the paper’s licence.
Not in our library
21.
Twelve years of SAMtools and BCFtools · 2021
No notice
22.
This reference’s wording can’t be shown under the paper’s licence.
Not in our library
23.
Pandemic preparedness and COVID-19: an exploratory analysis of infection and fatality rates, and contextual factors associated with preparedness in 177 countries, from Jan 1, 2020, to Sept 30, 2021 · 2022
No notice
24.
The changing epidemiology of human monkeypox—A potential threat? A systematic review · 2022
No notice
25.
This reference’s wording can’t be shown under the paper’s licence.
Not in our library
26.
The complete sequence of a human genome · 2022
No notice
27.
This reference’s wording can’t be shown under the paper’s licence.
Not in our library
28.
Epidemiological, clinical and virological characteristics of four cases of monkeypox support transmission through sexual contact, Italy, May 2022 · 2022
No notice
29.
This reference’s wording can’t be shown under the paper’s licence.
Not in our library
30.
Monkeypox infection presenting as genital rash, Australia, May 2022 · 2022
No notice
31.
This reference’s wording can’t be shown under the paper’s licence.
Not in our library
32.
Ongoing monkeypox virus outbreak, Portugal, 29 April to 23 May 2022 · 2022
No notice
33.
This reference’s wording can’t be shown under the paper’s licence.
Not in our library
34.
This reference’s wording can’t be shown under the paper’s licence.
Not in our library
35.
This reference’s wording can’t be shown under the paper’s licence.
Not in our library
36.
Estimated incubation period for monkeypox cases confirmed in the Netherlands, May 2022 · 2022
Corrected
37.
Clinical and virological features of first human monkeypox cases in Germany · 2022
No notice
38.
Frequent detection of monkeypox virus DNA in saliva, semen, and other clinical samples from 12 patients, Barcelona, Spain, May to June 2022 · 2022
No notice
39.
This reference’s wording can’t be shown under the paper’s licence.
Not in our library
40.
This reference’s wording can’t be shown under the paper’s licence.
Not in our library

Cited by papers we hold 1

Monkeypox: epidemiology, pathogenesis, treatment and prevention · 2022
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