The sea lamprey germline genome provides insights into programmed genome rearrangement and vertebrate evolution

Abstract

The sea lamprey ( Petromyzon marinus ) serves as a comparative model for reconstructing vertebrate evolution. To enable more informed analyses, we developed a new assembly of the lamprey germline genome that integrates several complementary data sets. Analysis of this highly contiguous (chromosome-scale) assembly shows that both chromosomal and whole-genome duplications have played significant roles in the evolution of ancestral vertebrate and lamprey genomes, including chromosomes that carry the six lamprey HOX clusters. The assembly also contains several hundred genes that are reproducibly eliminated from somatic cells during early development in lamprey. Comparative analyses show that gnathostome (mouse) homologs of these genes are frequently marked by polycomb repressive complexes (PRCs) in embryonic stem cells, suggesting overlaps in the regulatory logic of somatic DNA elimination and bivalent states that are regulated by early embryonic PRCs. This new assembly will enhance diverse studies that are informed by lampreys’ unique biology and evolutionary/comparative perspective.

Cited by papers we hold 6

• Hagfish genome elucidates vertebrate whole-genome duplication events and their evolutionary consequences · 2024
  No notice
• Reconstruction of proto-vertebrate, proto-cyclostome and proto-gnathostome genomes provides new insights into early vertebrate evolution · 2021
  Corrected
• Deeply conserved synteny resolves early events in vertebrate evolution · 2020
  No notice
• Apollo: Democratizing genome annotation · 2019
  No notice
• Tandem repeats lead to sequence assembly errors and impose multi-level challenges for genome and protein databases · 2019
  No notice
• Chromosome evolution at the origin of the ancestral vertebrate genome · 2018
  No notice

Reads

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.