A comparative genomics multitool for scientific discovery and conservation

Abstract

The Zoonomia Project is investigating the genomics of shared and specialized traits in eutherian mammals. Here we provide genome assemblies for 131 species, of which all but 9 are previously uncharacterized, and describe a whole-genome alignment of 240 species of considerable phylogenetic diversity, comprising representatives from more than 80% of mammalian families. We find that regions of reduced genetic diversity are more abundant in species at a high risk of extinction, discern signals of evolutionary selection at high resolution and provide insights from individual reference genomes. By prioritizing phylogenetic diversity and making data available quickly and without restriction, the Zoonomia Project aims to support biological discovery, medical research and the conservation of biodiversity.

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Cited by papers we hold 6

• Genome sequencing of 2000 canids by the Dog10K consortium advances the understanding of demography, genome function and architecture · 2023
  Corrected
• Identification of constrained sequence elements across 239 primate genomes · 2023
  No notice
• GENCODE: reference annotation for the human and mouse genomes in 2023 · 2022
  No notice
• The UCSC Genome Browser database: 2023 update · 2022
  No notice
• Highly contiguous assemblies of 101 drosophilid genomes · 2021
  Corrected
• Progressive Cactus is a multiple-genome aligner for the thousand-genome era · 2020
  No notice

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