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Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

Xiang Gui, Hui Yang, Tuo Li and 5 more

Nature · 2019

doi:10.1038/s41586-019-1006-9

References 31

  1. 1.

    Sun L, Wu J, Du F, Chen X & Chen ZJ Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 339, 786–791, doi: (2013 ).

    Not in our library10.1126/science.1232458

  2. 2.

    Wu J Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science 339, 826–830, doi: (2013 ).

    Not in our library10.1126/science.1229963

  3. 3.

    Ishikawa H & Barber GN STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature 455, 674–678, doi: (2008 ).

    Not in our library10.1038/nature07317

  4. 4.

    Wu J & Chen ZJ Innate immune sensing and signaling of cytosolic nucleic acids. Annu Rev Immunol 32, 461–488, doi: (2014 ).

    Not in our library10.1146/annurev-immunol-032713-120156

  5. 5.

    Zhong B The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity 29, 538–550, doi: (2008 ).

    Not in our library10.1016/j.immuni.2008.09.003

  6. 6.

    Crowl JT, Gray EE, Pestal K, Volkman HE & Stetson DB Intracellular Nucleic Acid Detection in Autoimmunity. Annu Rev Immunol 35, 313–336, doi: (2017 ).

    Not in our library10.1146/annurev-immunol-051116-052331

  7. 7.

    Kranzusch PJ Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2’,3’ cGAMP Signaling. Mol Cell 59, 891–903, doi: (2015 ).

    Not in our library10.1016/j.molcel.2015.07.022

  8. 8.
  9. 9.
  10. 10.

    Kim J Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell 152, 290–303, doi: (2013 ).

    Not in our library10.1016/j.cell.2012.12.016

  11. 11.

    Russell RC ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. Nat Cell Biol 15, 741–750, doi: (2013 ).

    Not in our library10.1038/ncb2757

  12. 12.
  13. 13.

    He R, Peng J, Yuan P, Xu F & Wei W Divergent roles of BECN1 in LC3 lipidation and autophagosomal function. Autophagy 11, 740–747, doi: (2015 ).

    Not in our library10.1080/15548627.2015.1034404

  14. 14.

    Jaber N Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function. Proc Natl Acad Sci U S A 109, 2003–2008, doi: (2012 ).

    Not in our library10.1073/pnas.1112848109

  15. 15.

    Brandizzi F & Barlowe C Organization of the ER-Golgi interface for membrane traffic control. Nat Rev Mol Cell Biol 14, 382–392, doi: (2013 ).

    Not in our library10.1038/nrm3588

  16. 16.

    Ge L, Baskaran S, Schekman R & Hurley JH The protein-vesicle network of autophagy. Curr Opin Cell Biol 29, 18–24, doi: (2014 ).

    Not in our library10.1016/j.ceb.2014.02.005

  17. 17.

    D’Souza-Schorey C & Chavrier P ARF proteins: roles in membrane traffic and beyond. Nat Rev Mol Cell Biol 7, 347–358, doi: (2006 ).

    Not in our library10.1038/nrm1910

  18. 18.

    Choy A The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation. Science 338, 1072–1076, doi: (2012 ).

    Not in our library10.1126/science.1227026

  19. 19.

    Tanaka Y & Chen ZJ STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway. Sci Signal 5, ra20, doi: (2012 ).

    Not in our library10.1126/scisignal.2002521

  20. 20.

    Liu S Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation. Science 347, aaa2630, doi: (2015 ).

    Not in our library10.1126/science.aaa2630

  21. 21.

    Zhang X Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol Cell 51, 226–235, doi: (2013 ).

    Not in our library10.1016/j.molcel.2013.05.022

  22. 22.

    Seth RB, Sun L, Ea CK & Chen ZJ Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell 122, 669–682, doi: (2005 ).

    Not in our library10.1016/j.cell.2005.08.012

  23. 23.

    Tanaka Y & Chen ZJ STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway. Sci Signal 5, ra20, doi: (2012 ).

    Not in our library10.1126/scisignal.2002521

  24. 24.

    Liu S Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation. Science 347, aaa2630, doi: (2015 ).

    Not in our library10.1126/science.aaa2630

  25. 25.

    Gao D Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses. Science 341, 903–906, doi: (2013 ).

    Not in our library10.1126/science.1240933

  26. 26.

    Shalem O Genome-scale CRISPR-Cas9 knockout screening in human cells. Science 343, 84–87, doi: (2014 ).

    Not in our library10.1126/science.1247005

  27. 27.

    Li XD Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects. Science 341, 1390–1394, doi: (2013 ).

    Not in our library10.1126/science.1244040

  28. 28.

    Sauer JD The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides. Infect Immun 79, 688–694, doi: (2011 ).

    Not in our library10.1128/iai.00999-10

  29. 29.

    Yang H, Wang H, Ren J, Chen Q & Chen ZJ cGAS is essential for cellular senescence. Proc Natl Acad Sci U S A 114, E4612–E4620, doi: (2017 ).

    Not in our library10.1073/pnas.1705499114

  30. 30.
  31. 31.

    Gao D Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases. Proc Natl Acad Sci U S A 112, E5699–5705, doi: (2015 ).

    Not in our library10.1073/pnas.1516465112

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