Pharmacological inhibition of Lin28 promotes ketogenesis and restores lipid homeostasis in models of non-alcoholic fatty liver disease
Evangelia Lekka, Aleksandra Kokanovic, Simone Mosole and 9 more
Nature Communications · 2022
doi:10.1038/s41467-022-35481-1 (opens in a new tab)
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Abstract
The Lin28/let-7 axis regulates metabolic pathways in normal and pathological contexts. Here the authors show that pharmacological inhibition of Lin28 protects against lipid accumulation in multiple preclinical models of nonalcoholic fatty liver disease.
Abstract licence: CC BY-NC-ND
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