Translation regulatory factor BZW1 regulates preimplantation embryo development and compaction by restricting global non-AUG Initiation
Jue Zhang, Shuai-Bo Pi, Nan Zhang and 5 more
Nature Communications · 2022
doi:10.1038/s41467-022-34427-x (opens in a new tab)
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Abstract
It is unclear how translational efficiency and codon stringency affect zygotic genome activation and early embryonic development. Here they show that the zygotic gene BZW1 increases start codon stringency, which is important for preimplantation development.
Abstract licence: CC BY-NC-ND
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