On-microscope staging of live cells reveals changes in the dynamics of transcriptional bursting during differentiation
D. M. Jeziorska, E. A. J. Tunnacliffe, J. M. Brown and 8 more
Nature Communications · 2022
doi:10.1038/s41467-022-33977-4 (opens in a new tab)
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Abstract
Here the authors observe transcription dynamics in real-time throughout erythropoiesis by combining PP7 tagging of α-globin RNA transcripts and “on-microscope” cell staging. They show how the pattern of transcriptional bursting changes during differentiation, with variability in individual cells significantly reduced at the peak period of gene expression.
Abstract licence: CC BY-NC-ND
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