No retraction, correction or concern found when last checked on Oct 29, 2026.
A consensus statement on detection of hippocampal sharp wave ripples and differentiation from other fast oscillations
Anli A. Liu, Simon Henin, Saman Abbaspoor and 32 more
Nature Communications · 2022 · Review · CC BY-NC-SA
doi:10.1038/s41467-022-33536-x
Abstract
Decades of rodent research have established the role of hippocampal sharp wave ripples (SPW-Rs) in consolidating and guiding experience. More recently, intracranial recordings in humans have suggested their role in episodic and semantic memory. Yet, common standards for recording, detection, and reporting do not exist. Here, we outline the methodological challenges involved in detecting ripple events and offer practical recommendations to improve separation from other high-frequency oscillations. We argue that shared experimental, detection, and reporting standards will provide a solid foundation for future translational discovery.
References 166
- 1.
Payne HL, Lynch GF, Aronov D. Neural representations of space in the hippocampus of a food-caching bird. Science. 2021;373:343-348.
Not in our library10.1126/science.abg2009
- 2.
Shein-Idelson M, Ondracek JM, Liaw HP, Reiter S, Laurent G. Slow waves, sharp waves, ripples, and REM in sleeping dragons. Science. 2016;352:590-595.
Not in our library10.1126/science.aaf3621
- 3.
Girardeau G, Benchenane K, Wiener SI, Buzsaki G, Zugaro MB. Selective suppression of hippocampal ripples impairs spatial memory. Nat. Neurosci. 2009;12:1222-1223.
Not in our library10.1038/nn.2384
- 4.
Ego-Stengel V, Wilson MA. Disruption of ripple-associated hippocampal activity during rest impairs spatial learning in the rat. Hippocampus. 2010;20:1-10.
Not in our library10.1002/hipo.20707
- 5.
Fernandez-Ruiz A, et al. Long-duration hippocampal sharp wave ripples improve memory. Science. 2019;364:1082-1086.
Not in our library10.1126/science.aax0758
- 6.
Gelinas JN, Khodagholy D, Thesen T, Devinsky O, Buzsaki G. Interictal epileptiform discharges induce hippocampal-cortical coupling in temporal lobe epilepsy. Nat. Med. 2016;22:641-648.
Not in our library10.1038/nm.4084
- 7.
Zhang Y, et al. Cholinergic suppression of hippocampal sharp-wave ripples impairs working memory. Proc. Natl Acad. Sci. USA. 2021;118:1-8.
Not in our library10.1073/pnas.2016432118
- 8.
Csicsvari J, Hirase H, Czurko A, Mamiya A, Buzsaki G. Fast network oscillations in the hippocampal CA1 region of the behaving rat. J. Neurosci. 1999;19:RC20.
Not in our library10.1523/jneurosci.19-16-j0001.1999
- 9.
Logothetis NK, et al. Hippocampal-cortical interaction during periods of subcortical silence. Nature. 2012;491:547-553.
Not in our library10.1038/nature11618
- 10.
Tingley D, Buzsaki G. Routing of hippocampal ripples to subcortical structures via the lateral septum. Neuron. 2020;105:138-149 e135.
Not in our library10.1016/j.neuron.2019.10.012
- 11.
Sjulson L, Peyrache A, Cumpelik A, Cassataro D, Buzsaki G. Cocaine place conditioning strengthens location-specific hippocampal coupling to the nucleus accumbens. Neuron. 2018;98:926-934 e925.
Not in our library10.1016/j.neuron.2018.04.015
- 12.
Skelin I, et al. Coupling between slow waves and sharp-wave ripples engages distributed neural activity during sleep in humans. Proc. Natl Acad. Sci. USA. 2021;118:1-10.
Not in our library10.1073/pnas.2012075118
- 13.
Diba K, Buzsaki G. Forward and reverse hippocampal place-cell sequences during ripples. Nat. Neurosci. 2007;10:1241-1242.
Not in our library10.1038/nn1961
- 14.
Foster DJ, Wilson MA. Reverse replay of behavioural sequences in hippocampal place cells during the awake state. Nature. 2006;440:680-683.
Not in our library10.1038/nature04587
- 15.
Wilson MA, McNaughton BL. Reactivation of hippocampal ensemble memories during sleep. Science. 1994;265:676-679.
Not in our library10.1126/science.8036517
- 16.
Gupta AS, van der Meer MA, Touretzky DS, Redish AD. Hippocampal replay is not a simple function of experience. Neuron. 2010;65:695-705.
Not in our library10.1016/j.neuron.2010.01.034
- 17.
Pfeiffer BE, Foster DJ. Hippocampal place-cell sequences depict future paths to remembered goals. Nature. 2013;497:74-79.
Not in our library10.1038/nature12112
- 18.
Gillespie AK, et al. Hippocampal replay reflects specific past experiences rather than a plan for subsequent choice. Neuron. 2021;109:3149-3163.e3146.
Not in our library10.1016/j.neuron.2021.07.029
- 19.
Carr MF, Jadhav SP, Frank LM. Hippocampal replay in the awake state: a potential substrate for memory consolidation and retrieval. Nat. Neurosci. 2011;14:147-153.
Not in our library10.1038/nn.2732
- 20.
Buzsaki G. Hippocampal sharp wave-ripple: a cognitive biomarker for episodic memory and planning. Hippocampus. 2015;25:1073-1188.
Not in our library10.1002/hipo.22488
- 21.
Joo HR, Frank LM. The hippocampal sharp wave-ripple in memory retrieval for immediate use and consolidation. Nat. Rev. Neurosci. 2018;19:744-757.
Not in our library10.1038/s41583-018-0077-1
- 22.
Leonard TK, Hoffman KL. Sharp-wave ripples in primates are enhanced near remembered visual objects. Curr. Biol. 2017;27:257-262.
Not in our library10.1016/j.cub.2016.11.027
- 23.
Foster DJ. Replay comes of age. Annu. Rev. Neurosci. 2017;40:581-602.
Not in our library10.1146/annurev-neuro-072116-031538
- 24.
- 25.
Sullivan D, et al. Relationships between hippocampal sharp waves, ripples, and fast gamma oscillation: influence of dentate and entorhinal cortical activity. J. Neurosci. 2011;31:8605-8616.
Not in our library10.1523/jneurosci.0294-11.2011
- 26.
Buzsaki G, Leung LW, Vanderwolf CH. Cellular bases of hippocampal EEG in the behaving rat. Brain Res. 1983;287:139-171.
Not in our library10.1016/0165-0173(83)90037-1
- 27.
Buzsaki G, Horvath Z, Urioste R, Hetke J, Wise K. High-frequency network oscillation in the hippocampus. Science. 1992;256:1025-1027.
Not in our library10.1126/science.1589772
- 28.
O’Keefe, J. & Nadel, L. The hippocampus as a cognitive map (Oxford University Press, 1978).
Not in our library
- 29.
Ylinen A, et al. Sharp wave-associated high-frequency oscillation (200 Hz) in the intact hippocampus: network and intracellular mechanisms. J. Neurosci. 1995;15:30-46.
Not in our library10.1523/jneurosci.15-01-00030.1995
- 30.
Stark E, et al. Pyramidal cell-interneuron interactions underlie hippocampal ripple oscillations. Neuron. 2014;83:467-480.
Not in our library10.1016/j.neuron.2014.06.023
- 31.
Buzsaki G. Hippocampal sharp waves: their origin and significance. Brain Res. 1986;398:242-252.
Not in our library10.1016/0006-8993(86)91483-6
- 32.
Schomburg EW, Anastassiou CA, Buzsaki G, Koch C. The spiking component of oscillatory extracellular potentials in the rat hippocampus. J. Neurosci. 2012;32:11798-11811.
Not in our library10.1523/jneurosci.0656-12.2012
- 33.
Oliva A, Fernandez-Ruiz A, Buzsaki G, Berenyi A. Role of hippocampal CA2 region in triggering sharp-wave ripples. Neuron. 2016;91:1342-1355.
Not in our library10.1016/j.neuron.2016.08.008
- 34.
Vaz AP, Inati SK, Brunel N, Zaghloul KA. Coupled ripple oscillations between the medial temporal lobe and neocortex retrieve human memory. Science. 2019;363:975-978.
Not in our library10.1126/science.aau8956
- 35.
Vaz AP, Wittig JH, Inati SK, Zaghloul KA. Replay of cortical spiking sequences during human memory retrieval. Science. 2020;367:1131-1134.
Not in our library10.1126/science.aba0672
- 36.
Norman Y, et al. Hippocampal sharp-wave ripples linked to visual episodic recollection in humans. Science. 2019;365:1-14.
Not in our library10.1126/science.aax1030
- 37.
Norman Y, Raccah O, Liu S, Parvizi J, Malach R. Hippocampal ripples and their coordinated dialogue with the default mode network during recent and remote recollection. Neuron. 2021;109:2767-2780.e2765.
Not in our library10.1016/j.neuron.2021.06.020
- 38.
- 39.
Henin S, et al. Spatiotemporal dynamics between interictal epileptiform discharges and ripples during associative memory processing. Brain. 2021;144:1590-1602.
Not in our library10.1093/brain/awab044
- 40.
de Sousa, B.M. et al. An open-source, ready-to-use and validated ripple detector plugin for the Open Ephys GUI. bioRxiv10.1101/2022.04.01.486754 (2022).
Not in our library10.1088/1741-2552/ac857b
Cited by papers we hold 1
Reads
Read by people on this page
None yet.
Checked or read by AI through naulon
None yet.
A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.
Are you an author?
Is this your paper?
Claim it to add your note and be paid when agents cite it. Free.