Exploration of nuclear body-enhanced sumoylation reveals that PML represses 2-cell features of embryonic stem cells
Sarah Tessier, Omar Ferhi, Marie-Claude Geoffroy and 12 more
Nature Communications · 2022
doi:10.1038/s41467-022-33147-6 (opens in a new tab)
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Abstract
Here the authors identify novel PML-partners and demonstrate that PML NBs control their sumoylation and that PML-controlled sumoylation of transcriptional regulators maintains the embryonic stem cell transcriptome and transposable element silencing.
Abstract licence: CC BY-NC-ND
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