Loop-extrusion and polymer phase-separation can co-exist at the single-molecule level to shape chromatin folding
Mattia Conte, Ehsan Irani, Andrea M. Chiariello and 4 more
Nature Communications · 2022
doi:10.1038/s41467-022-31856-6 (opens in a new tab)
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Abstract
Two main mechanisms have been proposed to shape 3D genome architecture - loop extrusion and phase separation. Here the authors combine these mechanisms in polymer models in a manner that best fits 3D genome, based on both Hi-C and super-resolution locus imaging data, proposing that these two physical processes can indeed coexist simultaneously within cells to define loops and TADs.
Abstract licence: CC BY-NC-ND
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