Microtubule disassembly by caspases is an important rate-limiting step of cell extrusion
Alexis Villars, Alexis Matamoro-Vidal, Florence Levillayer and 1 more
Nature Communications · 2022
doi:10.1038/s41467-022-31266-8 (opens in a new tab)
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Abstract
Using the Drosophila pupal notum, the authors demonstrate that the disassembly of microtubules by effector caspases initiate cell extrusion independently of actomyosin regulation, thus providing insights into how caspases orchestrate dying epithelial cell expulsion.
Abstract licence: CC BY-NC-ND
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