Nucleotide-amino acid π-stacking interactions initiate photo cross-linking in RNA-protein complexes
Anna Knörlein, Chris P. Sarnowski, Tebbe de Vries and 6 more
Nature Communications · 2022
doi:10.1038/s41467-022-30284-w (opens in a new tab)
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Abstract
Although UV-induced cross-linking is a widely used method to study RNA-protein complexes, the cross-linking reactions are poorly understood. Here, the authors show that π-stacking interactions between nucleobases and aromatic amino acids play a key role in the cross-linking process.
Abstract licence: CC BY-NC-ND
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