PI3Kγ stimulates a high molecular weight form of myosin light chain kinase to promote myeloid cell adhesion and tumor inflammation
Michael C. Schmid, Sang Won Kang, Hui Chen and 7 more
Nature Communications · 2022
doi:10.1038/s41467-022-29471-6 (opens in a new tab)
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Abstract
Myeloid cell recruitment during tumor inflammation depends on the VCAM-1 receptor integrin α4β1. Here the authors show that a high molecular weight form of myosin light chain kinase, MLCK210, is required for myeloid cell integrin α4β1 activation and adhesion and that MLCK210 inhibition reduces tumor growth and inflammation in preclinical cancer models.
Abstract licence: CC BY-NC-ND
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