Dissociation of tau pathology and neuronal hypometabolism within the ATN framework of Alzheimer’s disease
Michael Tran Duong, Sandhitsu R. Das, Xueying Lyu and 7 more
Nature Communications · 2022
doi:10.1038/s41467-022-28941-1 (opens in a new tab)
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Abstract
In Alzheimer’s disease (AD) tau and neurodegeneration have complex regional relationships. Here, the authors show neuronal hypometabolism discordant with tau burden defines functional resilience or susceptibility to Alzheimer’s pathology via limbic/cortical axes. Susceptible groups have faster cognitive decline and evidence of non-Alzheimer’s pathologies.
Abstract licence: CC BY-NC-ND
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