IL-22 initiates an IL-18-dependent epithelial response circuit to enforce intestinal host defence
Hung-Yu Chiang, Hsueh-Han Lu, Janaki N. Sudhakar and 4 more
Nature Communications · 2022
doi:10.1038/s41467-022-28478-3 (opens in a new tab)
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Abstract
IL-22 induces IL-18 expression by intestinal epithelial cells. Authors show here that IL-18 is a key barrier maintenance factor during adherent-invasive E. coli invasion, inducing expression of anti-microbial genes in Paneth cells via Stat3, prompting IFNγ expression in T cells and triggering intestinal Lgr5+ stem cell expansion via Tcf4.
Abstract licence: CC BY-NC-ND
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