Structural basis of the ligand binding and signaling mechanism of melatonin receptors
Qinggong Wang, Qiuyuan Lu, Qiong Guo and 6 more
Nature Communications · 2022
doi:10.1038/s41467-022-28111-3 (opens in a new tab)
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Abstract
Melatonin receptors (MT1 and MT2) are the targets for melatonin, the major neurohormone involved in circadian rhythm and sleep regulation. Here the authors describe the structures of 2-iodomelatonin and ramelteon bound MT1–Gi and MT2-Gi, revealing that MT1 and MT2 possess distinctive features within the ligand-binding pocket.
Abstract licence: CC BY-NC-ND
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