The combined DNA and RNA synthetic capabilities of archaeal DNA primase facilitate primer hand-off to the replicative DNA polymerase
Mark D. Greci, Joseph D. Dooher, Stephen D. Bell
Nature Communications · 2022
doi:10.1038/s41467-022-28093-2 (opens in a new tab)
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Abstract
DNA primases initiate a short primer before handing off to DNA polymerases to continue replication. Here the authors reveal a unique ability of archaeal primases to first synthesize RNA before stochastically incorporating a deoxyribonucleotide and further extending the primer as DNA.
Abstract licence: CC BY-NC-ND
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