Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca2+-dependent switch from intra- to intermembrane dimerization
Baobin Li, Christopher M. Hoel, Stephen G. Brohawn
Nature Communications · 2021
doi:10.1038/s41467-021-27283-8 (opens in a new tab)
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Abstract
Tweety Homologs (TTYHs) are highly conserved membrane proteins, whose functions remain poorly understood. Here, the authors present the cryo-EM structures of murine TTYH2 and TTYH3 that form cis-dimers in the presence of Ca2+, whereas in the absence of Ca2+ TTYH2 adopts monomeric and trans-dimeric structures. The presented structures lack ion conducting pathways, which is consistent with results from electrophysiology measurements.
Abstract licence: CC BY-NC-ND
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