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Compressive stress-mediated p38 activation required for ERα + phenotype in breast cancer

Pauliina M. Munne, Lahja Martikainen, Iiris Räty and 31 more

Nature Communications · 2021

doi:10.1038/s41467-021-27220-9 (opens in a new tab)

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Abstract

Reliable luminal estrogen receptor (ERα+) breast cancer models are limited. Here, the authors use patient derived breast epithelial and breast cancer explant cultures grown in several extracellular matrix scaffolds and show that ERα expression is regulated by matrix stiffness via stress-mediated p38 activation and H3K27me3-mediated epigenetic regulation.

Abstract licence: CC BY-NC-ND

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37 more references, whose wording the paper’s licence keeps private.

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