Trpm5 channels encode bistability of spinal motoneurons and ensure motor control of hindlimbs in mice
Rémi Bos, Benoît Drouillas, Mouloud Bouhadfane and 4 more
Nature Communications · 2021
doi:10.1038/s41467-021-27113-x (opens in a new tab)
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Abstract
The authors show that Trpm5, but not Trpm4, is the main Na+ -permeant channel mediating the warmth-activated ICaN in lumbar motoneurons. Trpm5 is also critical in generating plateau potentials in bistable motoneurons that are essential for producing a postural tone in hindlimbs and amplifying the locomotor output.
Abstract licence: CC BY-NC-ND
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