MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA
Qin Yu, Alba Herrero del Valle, Rahul Singh and 1 more
Nature Communications · 2021
doi:10.1038/s41467-021-27062-5 (opens in a new tab)
We email you when a new notice or a question about this paper appears.
Abstract
MDA5 is the primary immune sensor for SARS-CoV-2 and many other viruses. Mutations in MDA5 can cause disease. Here the authors employ CryoEM and biochemical methods to show how steric constraints cause MDA5 to misrecognize endogenous RNA as viral RNA.
Abstract licence: CC BY-NC-ND
Reads
Read by people on this page
None yet.
Checked or read by AI through naulon
None yet.
A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.
Are you an author?
Is this your paper?
Claim it to add your note and be paid when agents cite it. Free.