Mapping protein carboxymethylation sites provides insights into their role in proteostasis and cell proliferation
Simone Di Sanzo, Katrin Spengler, Anja Leheis and 11 more
Nature Communications · 2021
doi:10.1038/s41467-021-26982-6 (opens in a new tab)
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Abstract
Accumulation of advanced glycation end products such as carboxymethyllysine (CML) has been associated with aging but their molecular roles are largely unclear. Here, the authors use proteomics to identify CML sites and show that CML formation affects protein homeostasis and cell proliferation.
Abstract licence: CC BY-NC-ND
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