Changes in the distribution of fitness effects and adaptive mutational spectra following a single first step towards adaptation

Analyses of both natural and experimental evolution suggest that adaptation depends on the evolutionary past and adaptive potential decreases over time. Here, by tracking yeast adaptation with DNA barcoding, the authors show that such evolutionary phenomena can be observed even after a single adaptive step.

Abstract licence: CC BY-NC-ND

• Epistasis and evolution: recent advances and an outlook for prediction · 2023

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