Chd1 protects genome integrity at promoters to sustain hypertranscription in embryonic stem cells
Aydan Bulut-Karslioglu, Hu Jin, Yun-Kyo Kim and 8 more
Nature Communications · 2021
doi:10.1038/s41467-021-25088-3 (opens in a new tab)
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Abstract
The chromatin remodeler Chd1 mediates hypertranscription in embryonic stem (ES) cells and has been shown to associate with genes transcribed by RNA Polymerase (Pol) I and II. Here the authors provide mechanistic insights into this process and reveal that Chd1 is involved in protecting genome integrity at promoter regions by preventing DNA break accumulation.
Abstract licence: CC BY-NC-ND
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