Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer
Li-Yan Li, Qian Yang, Yan-Yi Jiang and 20 more
Nature Communications · 2021
doi:10.1038/s41467-021-24656-x (opens in a new tab)
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Abstract
The relevance and underlying molecular mechanisms of epigenetic regulation in squamous cell carcinomas (SCC) await further characterization. Here, the authors show a transcriptional regulatory loop involving SREBF1, TP63 and KLF5 driving tumourigenesis in SCC through fatty acid, ERBB and mTOR pathway regulation.
Abstract licence: CC BY-NC-ND
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