mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis
Rui Liu, Lin-Wen Zeng, Rong Gong and 3 more
Nature Communications · 2021
doi:10.1038/s41467-021-24321-3 (opens in a new tab)
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Abstract
An increase in glycine decarboxylase (GLDC) activity, a key enzyme for glycine catabolism, has been associated to tumourigenesis. Here, the authors show that mTORC1 activation induces GLDC deacetylation which impairs its ubiquitin-associated degradation leading to increased GLDC activity and tumourigenesis.
Abstract licence: CC BY-NC-ND
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